Agr2 anterior gradient 2, protein disulphide isomerase family member [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Agr2provided by RGD
Official Full Name: anterior gradient 2, protein disulphide isomerase family memberprovided by RGD
Primary source: RGD:1304606
See related: EnsemblRapid:ENSRNOG00000005023 AllianceGenome:RGD:1304606
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable dystroglycan binding activity; epidermal growth factor receptor binding activity; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of cell-substrate adhesion; positive regulation of protein localization to plasma membrane; and positive regulation of signal transduction. Predicted to act upstream of or within inflammatory response; lung goblet cell differentiation; and mucus secretion. Predicted to be located in extracellular space. Predicted to be active in endoplasmic reticulum. Orthologous to human AGR2 (anterior gradient 2, protein disulphide isomerase family member). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 55.6), Heart (RPKM 15.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (58435908..58456678)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (52708602..52729378)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (55465782..55487087)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that AGR2 is O-glycosylated upon secretion from human and rat cell lines, and that this form of the protein is released from healthy cells and not as a result of cell lysis.
Title: The metastasis-inducing protein AGR2 is O-glycosylated upon secretion from mammary epithelial cells.
AGR2 gene function requires a unique endoplasmic reticulum localization motif.
Title: AGR2 gene function requires a unique endoplasmic reticulum localization motif.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dystroglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables dystroglycan binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung goblet cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mucus secretion	ISO Inferred from Sequence Orthology more info
involved_in mucus secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of IRE1-mediated unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of PERK-mediated unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of developmental growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
NOT involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: anterior gradient protein 2 homolog

Names: anterior gradient 2 homolog; anterior gradient homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106725.1 → NP_001100195.1 anterior gradient protein 2 homolog precursor

See identical proteins and their annotated locations for NP_001100195.1

Status: PROVISIONAL

Source sequence(s)

CH473947

UniProtKB/TrEMBL

A6HBA4, D3ZIA7

Related

ENSRNOP00000006682.5, ENSRNOT00000006682.8

Conserved Domains (1) summary

cd02960
Location:47 → 175

AGR; Anterior Gradient (AGR) family; members of this family are similar to secreted proteins encoded by the cement gland-specific genes XAG-1 and XAG-2, expressed in the anterior region of dorsal ectoderm of Xenopus. They are implicated in the formation of ...
NM_001434243.1 → NP_001421172.1 anterior gradient protein 2 homolog precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6HBA4, D3ZIA7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

58435908..58456678

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240041.5 → XP_006240103.1 anterior gradient protein 2 homolog isoform X1

Conserved Domains (1) summary

cd02960
Location:47 → 175

AGR; Anterior Gradient (AGR) family; members of this family are similar to secreted proteins encoded by the cement gland-specific genes XAG-1 and XAG-2, expressed in the anterior region of dorsal ectoderm of Xenopus. They are implicated in the formation of ...