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    Tgs1 trimethylguanosine synthase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312947, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tgs1provided by RGD
    Official Full Name
    trimethylguanosine synthase 1provided by RGD
    Primary source
    RGD:1309953
    See related
    EnsemblRapid:ENSRNOG00000008156 AllianceGenome:RGD:1309953
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ncoa6ip
    Summary
    Predicted to enable RNA cap trimethylguanosine synthase activity. Predicted to be involved in 7-methylguanosine cap hypermethylation. Predicted to be located in cytosol. Predicted to be active in nucleus. Orthologous to human TGS1 (trimethylguanosine synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 72.8), Spleen (RPKM 57.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tgs1 in Genome Data Viewer
    Location:
    5q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (21322492..21356017)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (16524864..16558399)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (16413356..16446881)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103059 Neighboring gene transmembrane protein 68 Neighboring gene sterol carrier protein 2, pseudogene 1 Neighboring gene LYN proto-oncogene, Src family tyrosine kinase Neighboring gene uncharacterized LOC134486916

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PIMT Controls Insulin Synthesis and Secretion through PDX1. Sharma R, et al. Int J Mol Sci, 2023 Apr 29. PMID 37175791, Free PMC Article
    2. Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus. Enünlü I, et al. Biochem Biophys Res Commun, 2003 Sep 12. PMID 12943661
    3. Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies. Lemm I, et al. Mol Biol Cell, 2006 Jul. PMID 16687569, Free PMC Article
    4. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
    5. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PIMT Controls Insulin Synthesis and Secretion through PDX1.
      Title: PIMT Controls Insulin Synthesis and Secretion through PDX1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA cap trimethylguanosine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA cap trimethylguanosine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 7-methylguanosine cap hypermethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 7-methylguanosine cap hypermethylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    trimethylguanosine synthase
    Names
    PIMT
    PIPMT
    PRIP-interacting protein with methyltransferase motif
    nuclear receptor coactivator 6 interacting protein
    trimethylguanosine synthase homolog
    NP_001101374.1
    XP_038965688.1
    XP_063143595.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107904.1 → NP_001101374.1  trimethylguanosine synthase

      See identical proteins and their annotated locations for NP_001101374.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473984
      UniProtKB/Swiss-Prot
      P85107
      UniProtKB/TrEMBL
      A6JFK6
      Related
      ENSRNOP00000010783.5, ENSRNOT00000010783.7
      Conserved Domains (1) summary
      pfam09445
      Location:685 → 837
      Methyltransf_15; RNA cap guanine-N2 methyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      21322492..21356017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109760.2 → XP_038965688.1  trimethylguanosine synthase isoform X1

      Conserved Domains (2) summary
      NF033845
      Location:273 → 436
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl17173
      Location:684 → 836
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_063287525.1 → XP_063143595.1  trimethylguanosine synthase isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P85107.1 GenPept UniProtKB/Swiss-Prot:P85107

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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