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    Cenpu centromere protein U [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306464, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cenpuprovided by RGD
    Official Full Name
    centromere protein Uprovided by RGD
    Primary source
    RGD:1562566
    See related
    EnsemblRapid:ENSRNOG00000022261 AllianceGenome:RGD:1562566
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mlf1ip
    Summary
    Predicted to act upstream of or within chordate embryonic development. Predicted to be located in centriolar satellite; cytoplasm; and nucleoplasm. Predicted to be part of inner kinetochore. Predicted to be active in nucleus. Orthologous to human CENPU (centromere protein U). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 62.6), Spleen (RPKM 53.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cenpu in Genome Data Viewer
    Location:
    16q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (52448446..52471662, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (45715821..45739038, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (48898032..48921248, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L4, pseudogene 3 Neighboring gene caspase 3 Neighboring gene primase and DNA directed polymerase Neighboring gene acyl-CoA synthetase long-chain family member 1 Neighboring gene uncharacterized LOC108348397

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma. Hanissian SH, et al. Brain Res, 2005 Jun 14. PMID 15893739
    2. Investigation of tissue-specific expression and functions of MLF1-IP during development and in the immune system. Wang X, et al. PLoS One, 2013. PMID 23724000, Free PMC Article
    3. cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP. Hanissian SH, et al. Oncogene, 2004 Apr 29. PMID 15116101
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114444

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within chordate embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centromere protein U
    Names
    CENP-U
    MLF1-interacting protein
    myeloid leukemia factor 1 interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025673.1 → NP_001020844.1  centromere protein U

      See identical proteins and their annotated locations for NP_001020844.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097399
      UniProtKB/Swiss-Prot
      Q4V8G7
      UniProtKB/TrEMBL
      A0A8I5ZY64, A6JPN2
      Related
      ENSRNOP00000046417.3, ENSRNOT00000041596.6
      Conserved Domains (2) summary
      TIGR04523
      Location:276 → 355
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam13097
      Location:173 → 312
      CENP-U; CENP-A nucleosome associated complex (NAC) subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      52448446..52471662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8G7.1 GenPept UniProtKB/Swiss-Prot:Q4V8G7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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