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    Slc35d2 solute carrier family 35 member D2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290959, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc35d2provided by RGD
    Official Full Name
    solute carrier family 35 member D2provided by RGD
    Primary source
    RGD:1309518
    See related
    EnsemblRapid:ENSRNOG00000027229 AllianceGenome:RGD:1309518
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable antiporter activity and pyrimidine nucleotide-sugar transmembrane transporter activity. Predicted to be involved in nucleotide-sugar transmembrane transport. Predicted to act upstream of with a positive effect on heparan sulfate proteoglycan biosynthetic process. Predicted to be active in Golgi membrane. Orthologous to human SLC35D2 (solute carrier family 35 member D2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 61.1), Lung (RPKM 31.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc35d2 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (992153..1025476)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (987899..1019747)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (1618641..1649734, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene hyaluronan binding protein 4 Neighboring gene zinc finger protein 367 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 3 Neighboring gene ERCC excision repair 6 like 2 Neighboring gene uncharacterized LOC102554174

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables UDP-N-acetylgalactosamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-N-acetylglucosamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucuronic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide-sugar transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylgalactosamine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-N-acetylglucosamine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-glucuronic acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_positive_effect heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleotide-sugar transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleotide sugar transporter SLC35D2
    Names
    UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
    solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106098.2 → NP_001099568.2  nucleotide sugar transporter SLC35D2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      D4A1T9
      Related
      ENSRNOP00000038617.5, ENSRNOT00000036212.8
      Conserved Domains (1) summary
      cl26744
      Location:16 → 301
      TPT; Triose-phosphate Transporter family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      992153..1025476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253493.5 → XP_006253555.1  nucleotide sugar transporter SLC35D2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AC44
      Related
      ENSRNOP00000091466.1, ENSRNOT00000099057.2
      Conserved Domains (2) summary
      pfam03151
      Location:16 → 207
      TPT; Triose-phosphate Transporter family
      cl23754
      Location:102 → 174
      EamA; EamA-like transporter family

    2. XM_039095438.2 → XP_038951366.1  nucleotide sugar transporter SLC35D2 isoform X3

      Conserved Domains (1) summary
      cl26744
      Location:16 → 186
      TPT; Triose-phosphate Transporter family

    3. XM_039095437.2 → XP_038951365.1  nucleotide sugar transporter SLC35D2 isoform X2

      Conserved Domains (1) summary
      cl26744
      Location:17 → 210
      TPT; Triose-phosphate Transporter family
    Nucleotide Protein Strain
    Heading Accession and Version

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