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    Srsf10 serine and arginine rich splicing factor 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362630, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srsf10provided by RGD
    Official Full Name
    serine and arginine rich splicing factor 10provided by RGD
    Primary source
    RGD:1311067
    See related
    EnsemblRapid:ENSRNOG00000007992 AllianceGenome:RGD:1311067
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fusip1
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in cytosolic transport; mRNA splice site recognition; and negative regulation of mRNA splicing, via spliceosome. Located in axon terminus; dendrite; and neuronal cell body. Orthologous to human SRSF10 (serine and arginine rich splicing factor 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 221.6), Adrenal (RPKM 185.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srsf10 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153372307..153386520)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148088759..148102964)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154205358..154219550)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487011 Neighboring gene 60S acidic ribosomal protein P2-like Neighboring gene proline-rich nuclear receptor coactivator 2 Neighboring gene cannabinoid receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The expression and distribution of neural salient serine/arginine-rich protein 1 in rat retina. Peng ZY, et al. Neuroreport, 2007 Oct 29. PMID 17921860
    2. Expression analysis of an evolutionarily conserved alternative splicing factor, Sfrs10, in age-related macular degeneration. Karunakaran DK, et al. PLoS One, 2013. PMID 24098751, Free PMC Article
    3. Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing. Cowper AE, et al. J Biol Chem, 2001 Dec 28. PMID 11684676
    4. Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing. Xiao W, et al. Mol Cell, 2016 Feb 18. PMID 26876937
    5. Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. Yang L, et al. J Biol Chem, 1998 Oct 23. PMID 9774382

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112885

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing, via transesterification reactions ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cytosolic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splice site recognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 10
    Names
    FUS interacting protein (serine/arginine-rich) 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025738.2 → NP_001020909.1  serine/arginine-rich splicing factor 10 isoform 4

      See identical proteins and their annotated locations for NP_001020909.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D3ZB38, Q4KM38
      Conserved Domains (2) summary
      COG0724
      Location:6 → 164
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:10 → 93
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001399222.1 → NP_001386151.1  serine/arginine-rich splicing factor 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6A795
      Conserved Domains (1) summary
      cl17169
      Location:5 → 99
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001399223.1 → NP_001386152.1  serine/arginine-rich splicing factor 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      Conserved Domains (1) summary
      cl17169
      Location:5 → 99
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_001399224.1 → NP_001386153.1  serine/arginine-rich splicing factor 10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      Related
      ENSRNOP00000093859.2, ENSRNOT00000111665.2
      Conserved Domains (1) summary
      cd12559
      Location:5 → 99
      RRM_SRSF10; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 10 (SRSF10) and similar proteins

    5. NM_001399225.1 → NP_001386154.1  serine/arginine-rich splicing factor 10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IT67
      Related
      ENSRNOP00000108655.1, ENSRNOT00000126526.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      153372307..153386520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239220.5 → XP_006239282.1  serine/arginine-rich splicing factor 10 isoform X1

      See identical proteins and their annotated locations for XP_006239282.1

      UniProtKB/TrEMBL
      A0A8J8XB26
      Related
      ENSRNOP00000088158.2, ENSRNOT00000097808.2
      Conserved Domains (1) summary
      cl17169
      Location:5 → 99
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_006239222.5 → XP_006239284.1  serine/arginine-rich splicing factor 10 isoform X2

      See identical proteins and their annotated locations for XP_006239284.1

      UniProtKB/TrEMBL
      A0A8I6AMK7
      Conserved Domains (1) summary
      cd12559
      Location:5 → 99
      RRM_SRSF10; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 10 (SRSF10) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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