Rgmb repulsive guidance molecule BMP co-receptor b [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rgmbprovided by RGD
Full Name: repulsive guidance molecule BMP co-receptor bprovided by RGD
Primary source: RGD:1595392
See related: EnsemblRapid:ENSRNOG00000064721 AllianceGenome:RGD:1595392
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable coreceptor activity and identical protein binding activity. Predicted to be involved in BMP signaling pathway and positive regulation of DNA-templated transcription. Predicted to act upstream of or within cell adhesion. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment. Predicted to be active in plasma membrane. Orthologous to human RGMB (repulsive guidance molecule BMP co-receptor b). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 78.4), Brain (RPKM 74.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (65439748..65465149, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (56766598..56792396, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (57794046..57819941, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Curcumin mediates repulsive guidance molecule B (RGMb) in the treatment mechanism of renal fibrosis induced by unilateral ureteral obstruction.
Title: Curcumin mediates repulsive guidance molecule B (RGMb) in the treatment mechanism of renal fibrosis induced by unilateral ureteral obstruction.
RGMb expression in the uterus and ovary across the estrus cycle demonstrate that RGMb may be involved in the regulation of uterine function, follicular development as well as luteal activity.
Title: Expression of repulsive guidance molecule b (RGMb) in the uterus and ovary during the estrous cycle in rats.

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General gene information

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Markers

RH133573 (e-PCR)
- UniSTS:216856

RH143762 (e-PCR)
- UniSTS:233008

Rgmb (e-PCR), detects polymorphism
- UniSTS:508018

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables coreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: repulsive guidance molecule B; repulsive guidance molecule BMP co-receptor b

Names: RGM domain family, member B; repulsive guidance molecule family member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432539.1 → NP_001419468.1 repulsive guidance molecule BMP co-receptor b isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5ZSB8, A6KB58, M0RB24
NM_001432540.1 → NP_001419469.1 repulsive guidance molecule BMP co-receptor b isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5ZSB8, A6KB58, M0RB24
NM_001432541.1 → NP_001419470.1 repulsive guidance molecule BMP co-receptor b isoform b precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5ZSB8, A6KB58

RNA

NR_197298.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

65439748..65465149 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006227982.5 → XP_006228044.1 repulsive guidance molecule B

Related

ENSRNOP00000066746.2, ENSRNOT00000075401.3

Conserved Domains (2) summary

pfam06534
Location:270 → 449

RGM_C; Repulsive guidance molecule (RGM) C-terminus

pfam06535
Location:98 → 265

RGM_N; Repulsive guidance molecule (RGM) N-terminus