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Dicer1 dicer 1 ribonuclease III [ Rattus norvegicus (Norway rat) ]

Gene ID: 299284, updated on 9-Dec-2024

Summary

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Official Symbol: Dicer1provided by RGD
Official Full Name: dicer 1 ribonuclease IIIprovided by RGD
Primary source: RGD:1309381
See related: EnsemblRapid:ENSRNOG00000010711 AllianceGenome:RGD:1309381
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including double-stranded RNA binding activity; endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters; and regulatory RNA binding activity. Predicted to contribute to pre-miRNA binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of collagen biosynthetic process; and positive regulation of endothelial cell-matrix adhesion via fibronectin. Located in dendrite; endoplasmic reticulum-Golgi intermediate compartment; and growth cone. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in DICER1 syndrome; gastrointestinal system cancer (multiple); multinodular goiter; nephroma; and pleuropulmonary blastoma. Orthologous to human DICER1 (dicer 1, ribonuclease III). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 100.4), Adrenal (RPKM 100.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Dicer1 in Genome Data Viewer

Location:: 6q32

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (129392298..129457252, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (123627529..123692278, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (128388084..128453234, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II.
Title: The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II.
granulosa cells (GCs) of PCOS, the expression of miR-9119, and targeted NFkappaB/p65-DICER axis are upregulated in order to maintain cell viability and prevent apoptosis, thereby promoting Anti-Mullerian hormone production in GCs.
Title: MicroRNA-9119 regulates cell viability of granulosa cells in polycystic ovarian syndrome via mediating Dicer expression.
miR-107 could directly down-regulate Dicer-1.
Title: MicroRNA-107 contributes to post-stroke angiogenesis by targeting Dicer-1.
Dicer1 is essential for normal endothelial angiogenic processes, suggesting that age-related dysregulation of Dicer1-dependent miRNA expression may be a potential mechanism underlying impaired angiogenesis and cerebromicrovascular rarefaction in aging.
Title: Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
Dicer-substrate siRNA inhibits tumor necrosis factor alpha secretion by Kupffer cells.
Title: Dicer-substrate siRNA inhibits tumor necrosis factor alpha secretion in Kupffer cells in vitro: in vivo targeting of Kupffer cells by siRNA-liposomes.
we detected Dicer transcripts in 15 day rat lens, and detected Dicer protein in adult lens protein samples.
Title: miRNA and Dicer in the mammalian lens: expression of brain-specific miRNAs in the lens.
Dicer and microRNAs play a critical role in Schwann cell differentiation and myelination.
Title: Reduction of Dicer impairs Schwann cell differentiation and myelination.
Dicer is distributed in the Golgi-reticulum area in post-mitotic differentiated neuronal and glial cells; its profile is modulated during maturation and development of in vitro cultured cerebellar granule neurons.
Title: Dicer expression and localization in post-mitotic neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:498691 (e-PCR)
- UniSTS:498691

Dicer1 (e-PCR), detects polymorphism
- UniSTS:498691

Dicer1 (e-PCR), detects polymorphism
- UniSTS:498692

RH143307 (e-PCR)
- UniSTS:232554

Dicer1 (e-PCR), detects polymorphism
- UniSTS:525217

D6Got177 (e-PCR)
- UniSTS:114169

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA endonuclease activity	ISO Inferred from Sequence Orthology more info
enables deoxyribonuclease I activity	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables miRNA binding	ISO Inferred from Sequence Orthology more info
contributes_to pre-miRNA binding	ISO Inferred from Sequence Orthology more info
enables pre-miRNA binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables ribonuclease III activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonuclease III activity	ISO Inferred from Sequence Orthology more info
enables siRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RISC complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within RNA processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in apoptotic DNA fragmentation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac neural crest cell development involved in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cartilage development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cerebral cortex development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within digestive tract development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic hindlimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic limb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epidermis morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ganglion development	ISO Inferred from Sequence Orthology more info
acts_upstream_of gene expression	ISO Inferred from Sequence Orthology more info
involved_in global gene silencing by mRNA cleavage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear receptor cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intestinal epithelial cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in meiotic spindle organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in miRNA processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myoblast differentiation involved in skeletal muscle regeneration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Schwann cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nerve development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within olfactory bulb interneuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pericentric heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in peripheral nervous system myelin formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Schwann cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of establishment of endothelial barrier	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatic stellate cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of miRNA metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in pre-miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pre-miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in pre-miRNA processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of RNA metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of enamel mineralization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of miRNA metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulatory ncRNA-mediated post-transcriptional gene silencing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reproductive structure development	ISO Inferred from Sequence Orthology more info
involved_in siRNA processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within siRNA processing	ISO Inferred from Sequence Orthology more info
involved_in siRNA processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogonial cell division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord motor neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spindle assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spleen development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within trophectodermal cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within zygote asymmetric cell division	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
NOT part_of RISC complex	ISO Inferred from Sequence Orthology more info
part_of RISC complex	ISO Inferred from Sequence Orthology more info
part_of RISC-loading complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RISC-loading complex	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum-Golgi intermediate compartment	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endoribonuclease Dicer

Names: Dicer1, Dcr-1 homolog; dicer 1, ribonuclease type III

NP_001414144.1

EC 3.1.26.3

XP_017449994.1

EC 3.1.26.3

XP_038969286.1

EC 3.1.26.3

XP_038969290.1

EC 3.1.26.3

XP_038969291.1

EC 3.1.26.3

XP_038969292.1

EC 3.1.26.3

XP_063117841.1

EC 3.1.26.3

XP_063117842.1

EC 3.1.26.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427215.1 → NP_001414144.1 endoribonuclease Dicer

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6JER2, E9PU15

Related

ENSRNOP00000109133.1, ENSRNOT00000147513.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

129392298..129457252 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261772.1 → XP_063117842.1 endoribonuclease Dicer isoform X3

Related

ENSRNOP00000101022.1, ENSRNOT00000126505.1
XM_039113363.2 → XP_038969291.1 endoribonuclease Dicer isoform X2

Conserved Domains (8) summary

smart00535
Location:1266 → 1357

RIBOc; Ribonuclease III family

cd00593
Location:1648 → 1812

RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...

cd02843
Location:856 → 978

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:241 → 335

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:342 → 534

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:19 → 209

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

cd10843
Location:1817 → 1879

DSRM_DICER; double-stranded RNA binding motif of endoribonuclease Dicer and similar proteins

pfam03368
Location:600 → 688

Dicer_dimer; Dicer dimerization domain
XM_039113362.2 → XP_038969290.1 endoribonuclease Dicer isoform X2

Related

ENSRNOP00000014405.7, ENSRNOT00000014405.9

Conserved Domains (8) summary

smart00535
Location:1266 → 1357

RIBOc; Ribonuclease III family

cd00593
Location:1648 → 1812

RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...

cd02843
Location:856 → 978

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:241 → 335

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:342 → 534

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:19 → 209

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

cd10843
Location:1817 → 1879

DSRM_DICER; double-stranded RNA binding motif of endoribonuclease Dicer and similar proteins

pfam03368
Location:600 → 688

Dicer_dimer; Dicer dimerization domain
XM_039113358.2 → XP_038969286.1 endoribonuclease Dicer isoform X1

UniProtKB/TrEMBL

A6JER2, E9PU15

Conserved Domains (8) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

cd00593
Location:1678 → 1842

RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

cd10843
Location:1847 → 1909

DSRM_DICER; double-stranded RNA binding motif of endoribonuclease Dicer and similar proteins

pfam03368
Location:630 → 718

Dicer_dimer; Dicer dimerization domain
XM_039113364.2 → XP_038969292.1 endoribonuclease Dicer isoform X2

Conserved Domains (8) summary

smart00535
Location:1266 → 1357

RIBOc; Ribonuclease III family

cd00593
Location:1648 → 1812

RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...

cd02843
Location:856 → 978

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:241 → 335

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:342 → 534

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:19 → 209

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

cd10843
Location:1817 → 1879

DSRM_DICER; double-stranded RNA binding motif of endoribonuclease Dicer and similar proteins

pfam03368
Location:600 → 688

Dicer_dimer; Dicer dimerization domain
XM_063261771.1 → XP_063117841.1 endoribonuclease Dicer isoform X1

UniProtKB/TrEMBL

A6JER2, E9PU15
XM_017594505.3 → XP_017449994.1 endoribonuclease Dicer isoform X4