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    Clec12a C-type lectin domain family 12, member A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680338, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Clec12aprovided by RGD
    Official Full Name
    C-type lectin domain family 12, member Aprovided by RGD
    Primary source
    RGD:1592991
    See related
    EnsemblRapid:ENSRNOG00000054860 AllianceGenome:RGD:1592991
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable carbohydrate binding activity and signaling receptor regulator activity. Predicted to be located in membrane. Orthologous to human CLEC12A (C-type lectin domain family 12 member A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 58.2), Spleen (RPKM 46.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Clec12a in Genome Data Viewer
    Location:
    4q42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (164484162..164502793)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (162798125..162816757)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (163112100..163130979)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene Cd69 molecule Neighboring gene C-type lectin domain family 2, member M Neighboring gene chromatin target of PRMT1-like 1 Neighboring gene C-type lectin domain family 12, member B Neighboring gene C-type lectin domain family 1, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The uric acid crystal receptor Clec12A potentiates type I interferon responses. Li K, et al. Proc Natl Acad Sci U S A, 2019 Sep 10. PMID 31451663, Free PMC Article
    2. The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development. Raulf MK, et al. Cell Rep, 2019 Jul 2. PMID 31269448, Free PMC Article
    3. The complete inventory of receptors encoded by the rat natural killer cell gene complex. Flornes LM, et al. Immunogenetics, 2010 Aug. PMID 20544345, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC187973

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pattern recognition receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of natural killer cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neutrophil activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    C-type lectin domain family 12 member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134716.1 → NP_001128188.1  C-type lectin domain family 12 member A

      See identical proteins and their annotated locations for NP_001128188.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168186
      UniProtKB/TrEMBL
      B4F798, M0R761
      Related
      ENSRNOP00000073057.2, ENSRNOT00000087113.3
      Conserved Domains (1) summary
      cd03593
      Location:133 → 248
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      164484162..164502793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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