Mov10l1 Mov10 like RNA helicase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mov10l1provided by RGD
Official Full Name: Mov10 like RNA helicase 1provided by RGD
Primary source: RGD:1304735
See related: EnsemblRapid:ENSRNOG00000031093 AllianceGenome:RGD:1304735
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA helicase activity and piRNA binding activity. Predicted to be involved in several processes, including male meiosis I; regulatory ncRNA-mediated gene silencing; and spermatogenesis. Predicted to be located in pi-body. Predicted to be active in P granule and cytosol. Human ortholog(s) of this gene implicated in spermatogenic failure 73. Orthologous to human MOV10L1 (Mov10 like RNA helicase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 86.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (121949743..122015042)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (120070171..120135406)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (129973391..130039306)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables piRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in germ cell development	ISO Inferred from Sequence Orthology more info
involved_in male meiosis I	ISO Inferred from Sequence Orthology more info
involved_in male meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in piRNA processing	ISO Inferred from Sequence Orthology more info
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in transposable element silencing by piRNA-mediated DNA methylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in P granule	IBA Inferred from Biological aspect of Ancestor more info
located_in P granule	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in pi-body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA helicase Mov10l1

Names: Moloney leukemia virus 10-like 1; Mov10 RISC complex RNA helicase like 1; Mov10 like RISC complex RNA helicase 1; Mov10l1, Moloney leukemia virus 10-like 1, homolog

NP_001414417.1

EC 3.6.4.13

XP_006242311.3

EC 3.6.4.13

XP_017450774.3

EC 3.6.4.13

XP_017450775.3

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427488.1 → NP_001414417.1 RNA helicase Mov10l1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

Related

ENSRNOP00000039486.5, ENSRNOT00000042686.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

121949743..122015042

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595286.3 → XP_017450775.3 RNA helicase Mov10l1 isoform X2

UniProtKB/TrEMBL

D3ZH42
XM_017595285.3 → XP_017450774.3 RNA helicase Mov10l1 isoform X1

UniProtKB/TrEMBL

D3ZH42
XM_006242249.5 → XP_006242311.3 RNA helicase Mov10l1 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106787.1: Suppressed sequence

Description

NM_001106787.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: MOV10L1 (GeneID:54456).