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    Spata13 spermatogenesis associated 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305938, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spata13provided by RGD
    Official Full Name
    spermatogenesis associated 13provided by RGD
    Primary source
    RGD:1307364
    See related
    EnsemblRapid:ENSRNOG00000013707 AllianceGenome:RGD:1307364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and identical protein binding activity. Predicted to be involved in cell migration; plasma membrane bounded cell projection assembly; and regulation of cell migration. Predicted to be located in several cellular components, including filopodium; lamellipodium; and ruffle membrane. Predicted to be active in cytosol. Orthologous to human SPATA13 (spermatogenesis associated 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 175.4), Lung (RPKM 94.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spata13 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (38954585..39083752)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (34778479..34907645)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (40937652..41066645)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553694 Neighboring gene uncharacterized LOC120097002 Neighboring gene uncharacterized LOC120097003 Neighboring gene C1q and TNF related 9 Neighboring gene mitochondrial intermediate peptidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The guanine nucleotide exchange factor (GEF) Asef2 promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting. Evans JC, et al. J Biol Chem, 2015 Apr 17. PMID 25750125, Free PMC Article
    2. Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42. Kawasaki Y, et al. Oncogene, 2007 Dec 6. PMID 17599059
    3. Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration. Sagara M, et al. Oncogene, 2009 Mar 12. PMID 19151759
    4. Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. Hamann MJ, et al. Mol Cell Biol, 2007 Feb. PMID 17145773, Free PMC Article
    5. The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration. Bristow JM, et al. J Cell Sci, 2009 Dec 15. PMID 19934221, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The guanine nucleotide exchange factor (GEF) Asef2 (Spata13) promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting.
      Title: The guanine nucleotide exchange factor (GEF) Asef2 promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    spermatogenesis-associated protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431427.1 → NP_001418356.1  spermatogenesis-associated protein 13 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6ACW7, D3ZWB4

    2. NM_001431428.1 → NP_001418357.1  spermatogenesis-associated protein 13 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    3. NM_001431429.1 → NP_001418358.1  spermatogenesis-associated protein 13 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6A3P0, A6K6A4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      38954585..39083752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252113.5 → XP_006252175.1  spermatogenesis-associated protein 13 isoform X1

      Related
      ENSRNOP00000090978.2, ENSRNOT00000114572.2
      Conserved Domains (4) summary
      cd11973
      Location:727 → 798
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      cd01224
      Location:1021 → 1159
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:1049 → 1148
      PH; PH domain
      pfam00621
      Location:837 → 1016
      RhoGEF; RhoGEF domain

    2. XM_006252114.5 → XP_006252176.1  spermatogenesis-associated protein 13 isoform X2

      Related
      ENSRNOP00000106141.1, ENSRNOT00000126067.1
      Conserved Domains (4) summary
      cd11973
      Location:230 → 301
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      cd01224
      Location:524 → 662
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:552 → 651
      PH; PH domain
      pfam00621
      Location:340 → 519
      RhoGEF; RhoGEF domain

    3. XM_039093323.2 → XP_038949251.1  spermatogenesis-associated protein 13 isoform X4

      Conserved Domains (3) summary
      smart00325
      Location:84 → 263
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01224
      Location:268 → 406
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      cl17036
      Location:1 → 43
      SH3; Src Homology 3 domain superfamily

    4. XM_006252115.5 → XP_006252177.1  spermatogenesis-associated protein 13 isoform X3

      Related
      ENSRNOP00000087721.1, ENSRNOT00000115440.2
      Conserved Domains (4) summary
      cd11973
      Location:56 → 127
      SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
      cd01224
      Location:350 → 488
      PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:378 → 477
      PH; PH domain
      pfam00621
      Location:166 → 345
      RhoGEF; RhoGEF domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001191686.1: Suppressed sequence

      Description
      NM_001191686.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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