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    B3galnt1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310508, updated on 9-Dec-2024

    Summary

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    Official Symbol
    B3galnt1provided by RGD
    Official Full Name
    beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)provided by RGD
    Primary source
    RGD:1304797
    See related
    EnsemblRapid:ENSRNOG00000012019 AllianceGenome:RGD:1304797
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    B3galt3
    Summary
    Predicted to enable UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to act upstream of or within oligosaccharide biosynthetic process. Predicted to be active in Golgi membrane. Orthologous to human B3GALNT1 (beta-1,3-N-acetylgalactosaminyltransferase 1 (Globoside blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 141.1), Lung (RPKM 114.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See B3galnt1 in Genome Data Viewer
    Location:
    2q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (156157234..156187037, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (153847297..153877371, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (166226736..166255978, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 3b, pseudogene 2 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1L Neighboring gene ubiquitin-like modifier activating enzyme 3, pseudogene 1 Neighboring gene uncharacterized LOC134485628 Neighboring gene ATPase H+ transporting V1 subunit A, pseudogene 1 Neighboring gene phosphoserine aminotransferase 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genomic cloning and expression of three murine UDP-galactose: beta-N-acetylglucosamine beta1,3-galactosyltransferase genes. Hennet T, et al. J Biol Chem, 1998 Jan 2. PMID 9417047
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
    Names
    UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3
    UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1
    UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase
    b3Gal-T3
    beta-1,3-GalNAc-T1
    beta-1,3-GalTase 3
    beta-1,3-galactosyltransferase 3
    beta-3-GalNAc-T1
    beta-3-Gx-T3
    beta3Gal-T3
    beta3GalT3
    galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase
    globoside synthase
    NP_001013176.1
    XP_017446356.1
    XP_017446358.1
    XP_017446359.1
    XP_038958217.1
    XP_038958218.1
    XP_038958219.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013158.2 → NP_001013176.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

      See identical proteins and their annotated locations for NP_001013176.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q6AY39
      UniProtKB/TrEMBL
      A6J5N4
      Related
      ENSRNOP00000016012.3, ENSRNOT00000016012.7
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 285
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      156157234..156187037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590869.3 → XP_017446358.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AY39
      UniProtKB/TrEMBL
      A6J5N4
      Related
      ENSRNOP00000090178.1, ENSRNOT00000104541.2
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 285
      Galactosyl_T; Galactosyltransferase

    2. XM_017590870.3 → XP_017446359.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AY39
      UniProtKB/TrEMBL
      A6J5N4
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 285
      Galactosyl_T; Galactosyltransferase

    3. XM_017590867.3 → XP_017446356.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AY39
      UniProtKB/TrEMBL
      A6J5N4
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 285
      Galactosyl_T; Galactosyltransferase

    4. XM_039102289.2 → XP_038958217.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AY39
      UniProtKB/TrEMBL
      A6J5N4
      Related
      ENSRNOP00000090410.1, ENSRNOT00000099448.2
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 285
      Galactosyl_T; Galactosyltransferase

    5. XM_039102291.2 → XP_038958219.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AY39
      UniProtKB/TrEMBL
      A6J5N4
      Related
      ENSRNOP00000080226.1, ENSRNOT00000096998.2
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 285
      Galactosyl_T; Galactosyltransferase

    6. XM_039102290.2 → XP_038958218.1  UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AY39
      UniProtKB/TrEMBL
      A6J5N4
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 285
      Galactosyl_T; Galactosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY39.1 GenPept UniProtKB/Swiss-Prot:Q6AY39

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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