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    Pus7 pseudouridine synthase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296751, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pus7provided by RGD
    Official Full Name
    pseudouridine synthase 7provided by RGD
    Primary source
    RGD:1307054
    See related
    EnsemblRapid:ENSRNOG00000010572 AllianceGenome:RGD:1307054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307054
    Summary
    Predicted to enable enzyme binding activity and tRNA pseudouridine(13) synthase activity. Predicted to be involved in several processes, including pseudouridine synthesis; regulation of hematopoietic stem cell differentiation; and regulation of mesoderm development. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in intellectual developmental disorder with abnormal behavior, microcephaly, and short stature. Orthologous to human PUS7 (pseudouridine synthase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 60.3), Lung (RPKM 41.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pus7 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (12252553..12293547)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (11360169..11401139)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7889727..7931357)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 7 Neighboring gene RAD50 interactor 1 Neighboring gene small nucleolar RNA SNORD93 Neighboring gene uncharacterized LOC134486545 Neighboring gene SRSF protein kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells. Guzzi N, et al. Cell, 2018 May 17. PMID 29628141
    2. TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code. Safra M, et al. Genome Res, 2017 Mar. PMID 28073919, Free PMC Article
    3. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Armour SM, et al. Mol Cell Biol, 2013 Apr. PMID 23382074, Free PMC Article
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudouridine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA pseudouridine(13) synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA pseudouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of hematopoietic stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mesoderm development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA pseudouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pseudouridylate synthase 7 homolog
    NP_001164060.1
    XP_038963152.1
    XP_038963153.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170589.1 → NP_001164060.1  pseudouridylate synthase 7 homolog

      See identical proteins and their annotated locations for NP_001164060.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      D4ADZ9
      Related
      ENSRNOP00000014063.6, ENSRNOT00000014063.8
      Conserved Domains (1) summary
      cd02576
      Location:124 → 642
      PseudoU_synth_ScPUS7; Pseudouridine synthase, TruD family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      12252553..12293547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107224.2 → XP_038963152.1  pseudouridylate synthase 7 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQ13
      Related
      ENSRNOP00000080175.1, ENSRNOT00000105398.2
      Conserved Domains (1) summary
      cd02576
      Location:124 → 648
      PseudoU_synth_ScPUS7; Pseudouridine synthase, TruD family

    2. XM_039107225.2 → XP_038963153.1  pseudouridylate synthase 7 homolog isoform X2

      UniProtKB/TrEMBL
      A6K584
      Conserved Domains (1) summary
      cd02576
      Location:1 → 323
      PseudoU_synth_ScPUS7; Pseudouridine synthase, TruD family

    RNA

    1. XR_005503174.2 RNA Sequence

    2. XR_005503175.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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