Zkscan8 zinc finger with KRAB and SCAN domains 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zkscan8provided by RGD
Official Full Name: zinc finger with KRAB and SCAN domains 8provided by RGD
Primary source: RGD:1308983
See related: EnsemblRapid:ENSRNOG00000053635 AllianceGenome:RGD:1308983
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zfp192
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZKSCAN8 (zinc finger with KRAB and SCAN domains 8). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Brain (RPKM 49.7), Adrenal (RPKM 41.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (47735120..47753126)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (43039383..43057391)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (45078547..45105610)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein with KRAB and SCAN domains 8

Names: zinc finger protein 192

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100574.1 → NP_001094044.1 zinc finger protein with KRAB and SCAN domains 8

See identical proteins and their annotated locations for NP_001094044.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A6KN85, D4A3X9

Related

ENSRNOP00000068853.2, ENSRNOT00000088280.3

Conserved Domains (7) summary

smart00431
Location:48 → 158

SCAN; leucine rich region

cd07765
Location:230 → 268

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

COG5048
Location:322 → 574

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:446 → 466

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:388 → 410

zf-C2H2; Zinc finger, C2H2 type

pfam02023
Location:48 → 133

SCAN; SCAN domain

pfam13465
Location:515 → 538

zf-H2C2_2; Zinc-finger double domain