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    Fhod1 formin homology 2 domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291964, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fhod1provided by RGD
    Official Full Name
    formin homology 2 domain containing 1provided by RGD
    Primary source
    RGD:1589776
    See related
    EnsemblRapid:ENSRNOG00000054625 AllianceGenome:RGD:1589776
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity and identical protein binding activity. Predicted to be involved in cortical actin cytoskeleton organization; positive regulation of stress fiber assembly; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within establishment of centrosome localization and nuclear migration. Predicted to be located in several cellular components, including intercalated disc; nucleoplasm; and stress fiber. Predicted to be active in cytoplasm and cytoskeleton. Orthologous to human FHOD1 (formin homology 2 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 165.8), Muscle (RPKM 89.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fhod1 in Genome Data Viewer
    Location:
    19q11-q12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50116415..50135868, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33206492..33225448, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37284923..37303855, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 29 Neighboring gene transmembrane protein 208 Neighboring gene solute carrier family 9 member A5 Neighboring gene pleckstrin homology and RhoGEF domain containing G4 Neighboring gene potassium channel tetramerization domain containing 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel signaling axis of FHOD1-RNF213-Col1α/Col3α in the pathogenesis of hypertension-induced tunica media thickening. Chen Y, et al. J Mol Cell Cardiol, 2023 Sep. PMID 37482037
    2. Distribution of formins in cardiac muscle: FHOD1 is a component of intercalated discs and costameres. Al Haj A, et al. Eur J Cell Biol, 2015 Feb. PMID 25555464
    3. Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1. Schönichen A, et al. J Biol Chem, 2006 Feb 24. PMID 16361249
    4. The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells. Takeya R, et al. EMBO J, 2008 Feb 20. PMID 18239683, Free PMC Article
    5. Oligomerization of the diaphanous-related formin FHOD1 requires a coiled-coil motif critical for its cytoskeletal and transcriptional activities. Madrid R, et al. FEBS Lett, 2005 Jan 17. PMID 15642356

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel signaling axis of FHOD1-RNF213-Col1alpha/Col3alpha in the pathogenesis of hypertension-induced tunica media thickening.
      Title: Novel signaling axis of FHOD1-RNF213-Col1α/Col3α in the pathogenesis of hypertension-induced tunica media thickening.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within establishment of centrosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nuclear migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FH1/FH2 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395129.1 → NP_001382058.1  FH1/FH2 domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A0G2JZ38
      Related
      ENSRNOP00000070898.2, ENSRNOT00000084734.3
      Conserved Domains (3) summary
      PTZ00449
      Location:359 → 530
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam02181
      Location:631 → 1003
      FH2; Formin Homology 2 Domain
      pfam18382
      Location:17 → 115
      Formin_GBD_N; Formin N-terminal GTPase-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      50116415..50135868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772483.4 → XP_008770705.1  FH1/FH2 domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      pfam02181
      Location:657 → 1029
      FH2; Formin Homology 2 Domain

    2. XM_039097608.2 → XP_038953536.1  FH1/FH2 domain-containing protein 1 isoform X2

      Conserved Domains (2) summary
      PTZ00449
      Location:267 → 463
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam02181
      Location:564 → 936
      FH2; Formin Homology 2 Domain

    3. XM_039097609.2 → XP_038953537.1  FH1/FH2 domain-containing protein 1 isoform X3

      Conserved Domains (3) summary
      PTZ00449
      Location:360 → 556
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam18382
      Location:17 → 115
      Formin_GBD_N; Formin N-terminal GTPase-binding domain
      cl19758
      Location:661 → 874
      FH2; Formin Homology 2 Domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001191600.1: Suppressed sequence

      Description
      NM_001191600.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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