U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Ddhd2 DDHD domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680971, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ddhd2provided by RGD
    Official Full Name
    DDHD domain containing 2provided by RGD
    Primary source
    RGD:1585818
    See related
    EnsemblRapid:ENSRNOG00000015501 AllianceGenome:RGD:1585818
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phospholipase activity and triacylglycerol lipase activity. Predicted to act upstream of or within lipid droplet organization; positive regulation of mitochondrial fission; and triglyceride catabolic process. Predicted to be located in centriolar satellite and cytosol. Predicted to be active in COPII-coated ER to Golgi transport vesicle and membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 54. Orthologous to human DDHD2 (DDHD domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 207.0), Adrenal (RPKM 166.4) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ddhd2 in Genome Data Viewer
    Location:
    16q12.4
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (73022136..73051746)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (66319469..66349025)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71090096..71120713)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene LSM1 homolog, mRNA degradation associated Neighboring gene BAG cochaperone 4 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134482516 Neighboring gene phospholipid phosphatase 5 Neighboring gene nuclear receptor binding SET domain protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding  
    enables phospholipase activity  
    enables triacylglycerol lipase activity  
    enables triacylglycerol lipase activity  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle  
    located_in centriolar satellite  
    located_in centriolar satellite  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    is_active_in membrane  
    located_in membrane  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318416.1NP_001305345.1  phospholipase DDHD2

      Status: PROVISIONAL

      Source sequence(s)
      AB914679
      UniProtKB/TrEMBL
      A0A8I6AUM0, D3ZJ91
      Conserved Domains (4) summary
      smart00454
      Location:386445
      SAM; Sterile alpha motif
      pfam02825
      Location:42112
      WWE; WWE domain
      pfam02862
      Location:487687
      DDHD; DDHD domain
      cl15755
      Location:379447
      SAM_superfamily; SAM (Sterile alpha motif )

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      73022136..73051746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001059724.8XP_001059724.3  phospholipase DDHD2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AUM0, D3ZJ91
      Conserved Domains (4) summary
      smart00454
      Location:386445
      SAM; Sterile alpha motif
      pfam02825
      Location:42112
      WWE; WWE domain
      pfam02862
      Location:487687
      DDHD; DDHD domain
      cl15755
      Location:379447
      SAM_superfamily; SAM (Sterile alpha motif )
    2. XM_006253339.5XP_006253401.1  phospholipase DDHD2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AUM0, D3ZJ91
      Related
      ENSRNOP00000020832.8, ENSRNOT00000020832.10
      Conserved Domains (4) summary
      smart00454
      Location:386445
      SAM; Sterile alpha motif
      pfam02825
      Location:42112
      WWE; WWE domain
      pfam02862
      Location:487687
      DDHD; DDHD domain
      cl15755
      Location:379447
      SAM_superfamily; SAM (Sterile alpha motif )
    3. XM_063275720.1XP_063131790.1  phospholipase DDHD2 isoform X2

      UniProtKB/TrEMBL
      D3ZJ91
      Related
      ENSRNOP00000096096.2, ENSRNOT00000117689.2
    4. XM_008771368.3XP_008769590.1  phospholipase DDHD2 isoform X2

      UniProtKB/TrEMBL
      D3ZJ91
      Related
      ENSRNOP00000105009.1, ENSRNOT00000163681.1
      Conserved Domains (4) summary
      smart00454
      Location:386445
      SAM; Sterile alpha motif
      pfam02825
      Location:42112
      WWE; WWE domain
      pfam02862
      Location:470670
      DDHD; DDHD domain
      cl15755
      Location:379447
      SAM_superfamily; SAM (Sterile alpha motif )
    5. XM_039094820.2XP_038950748.1  phospholipase DDHD2 isoform X3

      UniProtKB/TrEMBL
      D3ZJ91
      Conserved Domains (3) summary
      pfam02825
      Location:44112
      WWE; WWE domain
      pfam02862
      Location:487672
      DDHD; DDHD domain
      cl15755
      Location:379447
      SAM_superfamily; SAM (Sterile alpha motif )
    6. XM_063275721.1XP_063131791.1  phospholipase DDHD2 isoform X4

      UniProtKB/TrEMBL
      D3ZJ91
    7. XM_006253338.4XP_006253400.1  phospholipase DDHD2 isoform X5

      UniProtKB/TrEMBL
      D3ZJ91
      Conserved Domains (3) summary
      smart00454
      Location:290349
      SAM; Sterile alpha motif
      pfam02862
      Location:391591
      DDHD; DDHD domain
      cl15755
      Location:283351
      SAM_superfamily; SAM (Sterile alpha motif )

    RNA

    1. XR_005494673.2 RNA Sequence

    Loading
    External link. Please review our privacy policy.