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    Mtmr10 myotubularin related protein 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309255, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mtmr10provided by RGD
    Official Full Name
    myotubularin related protein 10provided by RGD
    Primary source
    RGD:1305958
    See related
    EnsemblRapid:ENSRNOG00000016090 AllianceGenome:RGD:1305958
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305958
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be active in cytoplasm and membrane. Orthologous to human MTMR10 (myotubularin related protein 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 185.7), Lung (RPKM 106.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtmr10 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (127271139..127322621)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (117859355..117910839)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (125124743..125175857)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099837 Neighboring gene transient receptor potential cation channel, subfamily M, member 1 Neighboring gene microRNA 211 Neighboring gene FANCD2 and FANCI associated nuclease 1 Neighboring gene M-phase phosphoprotein 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. Lorenzo O, et al. J Cell Sci, 2006 Jul 15. PMID 16787938
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-3-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myotubularin-related protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100846.1 → NP_001094316.1  myotubularin-related protein 10

      See identical proteins and their annotated locations for NP_001094316.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6B2M4, A6JBK9, G3V810
      Related
      ENSRNOP00000096606.2, ENSRNOT00000114828.2
      Conserved Domains (3) summary
      cd13346
      Location:21 → 193
      PH-GRAM_MTMR10; Myotubularian (MTM) related 10 protein (MTMR10) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam12578
      Location:574 → 701
      3-PAP; Myotubularin-associated protein
      cl21483
      Location:222 → 503
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      127271139..127322621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079931.2 → XP_038935859.1  myotubularin-related protein 10 isoform X1

      UniProtKB/TrEMBL
      A0A8I6B2M4
      Conserved Domains (3) summary
      cd14593
      Location:193 → 386
      PTP-MTMR10; protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related phosphoinositide phosphatase 10
      pfam12578
      Location:492 → 619
      3-PAP; Myotubularin-associated protein
      cl17171
      Location:1 → 111
      PH-like; Pleckstrin homology-like domain

    2. XM_039079929.2 → XP_038935857.1  myotubularin-related protein 10 isoform X1

      UniProtKB/TrEMBL
      A0A8I6B2M4
      Conserved Domains (3) summary
      cd14593
      Location:193 → 386
      PTP-MTMR10; protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related phosphoinositide phosphatase 10
      pfam12578
      Location:492 → 619
      3-PAP; Myotubularin-associated protein
      cl17171
      Location:1 → 111
      PH-like; Pleckstrin homology-like domain

    3. XM_039079926.2 → XP_038935854.1  myotubularin-related protein 10 isoform X1

      UniProtKB/TrEMBL
      A0A8I6B2M4
      Conserved Domains (3) summary
      cd14593
      Location:193 → 386
      PTP-MTMR10; protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related phosphoinositide phosphatase 10
      pfam12578
      Location:492 → 619
      3-PAP; Myotubularin-associated protein
      cl17171
      Location:1 → 111
      PH-like; Pleckstrin homology-like domain

    4. XM_063264488.1 → XP_063120558.1  myotubularin-related protein 10 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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