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    Morc1 MORC family CW-type zinc finger 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360712, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Morc1provided by RGD
    Official Full Name
    MORC family CW-type zinc finger 1provided by RGD
    Primary source
    RGD:1565610
    See related
    EnsemblRapid:ENSRNOG00000032101 AllianceGenome:RGD:1565610
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Morc; RGD1565610
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of gene expression. Predicted to act upstream of or within several processes, including behavioral fear response; epigenetic regulation of gene expression; and negative regulation of DNA-templated transcription initiation. Predicted to be active in male germ cell nucleus. Orthologous to human MORC1 (MORC family CW-type zinc finger 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 138.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Morc1 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (65641786..65847257, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (52178769..52384255, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (54762654..55044581, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene T cell receptor associated transmembrane adaptor 1 Neighboring gene uncharacterized LOC134480996 Neighboring gene 60S ribosomal protein L9 pseudogene Neighboring gene chromosome 11 C3orf85 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Morc1 as a potential new target gene in mood regulation: when and where to find in the brain. Mundorf A, et al. Exp Brain Res, 2021 Oct. PMID 34331083, Free PMC Article
    2. Morc1 knockout evokes a depression-like phenotype in mice. Schmidt M, et al. Behav Brain Res, 2016 Jan 1. PMID 26275923
    3. Identification of morc (microrchidia), a mutation that results in arrest of spermatogenesis at an early meiotic stage in the mouse. Watson ML, et al. Proc Natl Acad Sci U S A, 1998 Nov 24. PMID 9826705, Free PMC Article
    4. New gene family defined by MORC, a nuclear protein required for mouse spermatogenesis. Inoue N, et al. Hum Mol Genet, 1999 Jul. PMID 10369865
    5. MORC1 represses transposable elements in the mouse male germline. Pastor WA, et al. Nat Commun, 2014 Dec 12. PMID 25503965, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Morc1 as a potential new target gene in mood regulation: when and where to find in the brain.
      Title: Morc1 as a potential new target gene in mood regulation: when and where to find in the brain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epigenetic programing of male pronucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epigenetic regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of retrotransposition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within transposable element silencing by heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MORC family CW-type zinc finger protein 1
    Names
    microrchidia 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172090.1 → NP_001165561.1  MORC family CW-type zinc finger protein 1

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6IQV9, D3ZKF3
      Related
      ENSRNOP00000046114.4, ENSRNOT00000046330.6
      Conserved Domains (2) summary
      pfam07496
      Location:481 → 526
      zf-CW; CW-type Zinc Finger
      cl00075
      Location:27 → 159
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      65641786..65847257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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