U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Popdc1 popeye domain cAMP effector 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365603, updated on 4-Jan-2025

    Summary

    Official Symbol
    Popdc1provided by RGD
    Official Full Name
    popeye domain cAMP effector 1provided by RGD
    Primary source
    RGD:1561100
    See related
    EnsemblRapid:ENSRNOG00000043199 AllianceGenome:RGD:1561100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bves
    Summary
    Predicted to enable cAMP binding activity and structural molecule activity. Predicted to be involved in several processes, including positive regulation of receptor recycling; response to ischemia; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within hematopoietic progenitor cell differentiation; regulation of heart rate; and sinoatrial node cell development. Predicted to be located in several cellular components, including bicellular tight junction; caveola; and lateral plasma membrane. Predicted to be active in sarcolemma. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2X. Orthologous to human POPDC1 (popeye domain cAMP effector 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Muscle (RPKM 132.1), Heart (RPKM 98.2) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Popdc1 in Genome Data Viewer
    Location:
    20q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (50401611..50442653)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (48819241..48860282)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (50439885..50474678)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene popeye domain cAMP effector 3 Neighboring gene lin-28 homolog B Neighboring gene lactate dehydrogenase A, pseudogene 20

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cAMP binding  
    enables cAMP binding  
    enables structural molecule activity  
    enables structural molecule activity  
    Items 1 - 25 of 29
    Process Evidence Code Pubs
    involved_in cell migration involved in heart development  
    involved_in epithelial cell-cell adhesion  
    involved_in epithelial cell-cell adhesion  
    involved_in heart development  
    involved_in heart development  
    involved_in heart development  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation  
    involved_in positive regulation of locomotion  
    involved_in positive regulation of locomotion  
    involved_in positive regulation of receptor recycling  
    involved_in positive regulation of receptor recycling  
    involved_in regulation of cell shape  
    involved_in regulation of cell shape  
    involved_in regulation of endocytic recycling  
    acts_upstream_of_or_within regulation of heart rate  
    involved_in regulation of membrane potential  
    acts_upstream_of_or_within regulation of membrane potential  
    involved_in response to ischemia  
    involved_in response to ischemia  
    acts_upstream_of_or_within sinoatrial node cell development  
    involved_in skeletal muscle tissue development  
    involved_in skeletal muscle tissue development  
    involved_in skeletal muscle tissue development  
    involved_in striated muscle cell differentiation  
    involved_in substrate adhesion-dependent cell spreading  
    involved_in substrate adhesion-dependent cell spreading  
    involved_in vesicle docking  
    involved_in vesicle-mediated transport  
    involved_in vesicle-mediated transport  
    Items 1 - 25 of 29
    Component Evidence Code Pubs
    located_in bicellular tight junction  
    located_in bicellular tight junction  
    located_in caveola  
    located_in caveola  
    located_in cell junction  
    located_in cell projection membrane  
    located_in lateral plasma membrane  
    located_in lateral plasma membrane  
    located_in membrane  
    located_in membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in sarcolemma  
    located_in sarcolemma  
    located_in sarcolemma  

    General protein information

    Preferred Names
    blood vessel epicardial substance
    Names
    popeye domain-containing 1
    popeye domain-containing protein 1
    popeye protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077590.3NP_001071058.1  blood vessel epicardial substance

      See identical proteins and their annotated locations for NP_001071058.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q3BCU4
      UniProtKB/TrEMBL
      A6K6V1
      Related
      ENSRNOP00000091870.2, ENSRNOT00000066167.6
      Conserved Domains (1) summary
      pfam04831
      Location:40266
      Popeye; Popeye protein conserved region
    2. NM_001434645.1NP_001421574.1  blood vessel epicardial substance

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q3BCU4
      UniProtKB/TrEMBL
      A6K6V1
    3. NM_001434646.1NP_001421575.1  blood vessel epicardial substance

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q3BCU4
      UniProtKB/TrEMBL
      A6K6V1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      50401611..50442653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098920.2XP_038954848.1  blood vessel epicardial substance isoform X2

      Conserved Domains (1) summary
      pfam04831
      Location:40180
      Popeye; Popeye protein conserved region
    2. XM_039098919.2XP_038954847.1  blood vessel epicardial substance isoform X1

      Conserved Domains (1) summary
      pfam04831
      Location:40266
      Popeye; Popeye protein conserved region
    3. XM_039098918.2XP_038954846.1  blood vessel epicardial substance isoform X1

      Related
      ENSRNOP00000105633.1, ENSRNOT00000162385.1
      Conserved Domains (1) summary
      pfam04831
      Location:40266
      Popeye; Popeye protein conserved region
    4. XM_039098917.2XP_038954845.1  blood vessel epicardial substance isoform X1

      Conserved Domains (1) summary
      pfam04831
      Location:40266
      Popeye; Popeye protein conserved region
    Loading
    External link. Please review our privacy policy.