Opalin oligodendrocytic myelin paranodal and inner loop protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Opalinprovided by RGD
Official Full Name: oligodendrocytic myelin paranodal and inner loop proteinprovided by RGD
Primary source: RGD:1307776
See related: EnsemblRapid:ENSRNOG00000022386 AllianceGenome:RGD:1307776
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmem10
Summary: Predicted to be involved in regulation of oligodendrocyte differentiation. Predicted to be located in Golgi apparatus. Predicted to be active in cell-cell contact zone and plasma membrane. Orthologous to human OPALIN (oligodendrocytic myelin paranodal and inner loop protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 204.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (249840539..249858423, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (239891137..239909388, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (260324028..260341677, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

highly sialylglycosylated Opalin has a role in an intermembranous function of the myelin paranodal loops in the central nervous system
Title: Opalin, a transmembrane sialylglycoprotein located in the central nervous system myelin paranodal loop membrane.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cell-cell contact zone	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: opalin

Names: transmembrane protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.