Eef2kmt eukaryotic elongation factor 2 lysine methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eef2kmtprovided by RGD
Official Full Name: eukaryotic elongation factor 2 lysine methyltransferaseprovided by RGD
Primary source: RGD:1304969
See related: EnsemblRapid:ENSRNOG00000002876 AllianceGenome:RGD:1304969
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam86a; RGD1304969
Summary: Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine trimethylation and regulation of translation. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Orthologous to several human genes including EEF2KMT (eukaryotic elongation factor 2 lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 63.3), Adrenal (RPKM 54.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (10843429..10853800)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (10336933..10349463)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (10530302..10540428)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D10Rat259 (e-PCR), detects polymorphism
- UniSTS:226368

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-lysine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine trimethylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein-lysine N-methyltransferase EEF2KMT

Names: family with sequence similarity 86, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106975.1 → NP_001100445.1 protein-lysine N-methyltransferase EEF2KMT

See identical proteins and their annotated locations for NP_001100445.1

Status: PROVISIONAL

Source sequence(s)

CH474017

UniProtKB/TrEMBL

A6K4N6, D3Z8P8

Related

ENSRNOP00000003843.4, ENSRNOT00000003843.6

Conserved Domains (2) summary

pfam14904
Location:6 → 99

FAM86; Family of unknown function

cl17173
Location:135 → 299

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

10843429..10853800

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085837.2 → XP_038941765.1 protein-lysine N-methyltransferase EEF2KMT isoform X2

Conserved Domains (2) summary

pfam14904
Location:6 → 99

FAM86; Family of unknown function

cl23717
Location:82 → 162

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
XM_006245785.5 → XP_006245847.1 protein-lysine N-methyltransferase EEF2KMT isoform X1

Conserved Domains (2) summary

pfam14904
Location:6 → 80

FAM86; Family of unknown function

cl17173
Location:101 → 265

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...