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    Dntt DNA nucleotidylexotransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294051, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnttprovided by RGD
    Official Full Name
    DNA nucleotidylexotransferaseprovided by RGD
    Primary source
    RGD:1305054
    See related
    EnsemblRapid:ENSRNOG00000013615 AllianceGenome:RGD:1305054
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA nucleotidylexotransferase activity. Involved in response to ATP. Located in euchromatin and nuclear matrix. Orthologous to human DNTT (DNA nucleotidylexotransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1500.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dntt in Genome Data Viewer
    Location:
    1q54
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (249805802..249837685)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (239856391..239888283)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (260289626..260321174)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 518A Neighboring gene B-cell linker Neighboring gene uncharacterized LOC120100035 Neighboring gene oligodendrocytic myelin paranodal and inner loop protein Neighboring gene uncharacterized LOC120100036 Neighboring gene tolloid-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Terminal transferase positive rat thymocytes are resistant to steroid-induced apoptosis. Trubiani O, et al. Cell Struct Funct, 1995 Dec. PMID 8825066
    2. Terminal deoxynucleotidyl transferase activity in neoplastic and nonneoplastic hematopoietic cells. Bearman RM, et al. Am J Clin Pathol, 1981 Jun. PMID 7020399
    3. Nuclear matrix bound terminal deoxynucleotidyl transferase in rat thymus nuclei. II. Effect of ATP on free and matrix bound TdT. Dave VP, et al. Mol Biol Rep, 1988-1989. PMID 3272345
    4. Nuclear matrix bound terminal deoxynucleotidyl transferase in rat thymus nuclei. I. A possible site for TdT mediated function. Pandey VN, et al. Mol Biol Rep, 1988-1989. PMID 3272344
    5. Differential splicing in mouse thymus generates two forms of terminal deoxynucleotidyl transferase. Doyen N, et al. Nucleic Acids Res, 1993 Mar 11. PMID 8464703, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC109152

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA nucleotidylexotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA nucleotidylexotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to ATP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA nucleotidylexotransferase
    Names
    deoxynucleotidyltransferase, terminal
    terminal deoxynucleotidyltransferase
    NP_001012479.1
    XP_038965077.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012461.1 → NP_001012479.1  DNA nucleotidylexotransferase

      See identical proteins and their annotated locations for NP_001012479.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089904
      UniProtKB/TrEMBL
      E9PT58, Q5EB91
      Related
      ENSRNOP00000051355.3, ENSRNOT00000051058.6
      Conserved Domains (3) summary
      cd00141
      Location:166 → 508
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      smart00292
      Location:32 → 111
      BRCT; breast cancer carboxy-terminal domain
      smart00483
      Location:163 → 509
      POLXc; DNA polymerase X family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      249805802..249837685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109149.2 → XP_038965077.1  DNA nucleotidylexotransferase isoform X1

      UniProtKB/TrEMBL
      E9PT58
      Related
      ENSRNOP00000099872.1, ENSRNOT00000149894.1
      Conserved Domains (2) summary
      smart00483
      Location:116 → 462
      POLXc; DNA polymerase X family
      cl00038
      Location:21 → 78
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    Nucleotide Protein Strain
    Heading Accession and Version

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