Has1 hyaluronan synthase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Has1provided by RGD
Official Full Name: hyaluronan synthase 1provided by RGD
Primary source: RGD:708528
See related: EnsemblRapid:ENSRNOG00000010994 AllianceGenome:RGD:708528
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable hyaluronan synthase activity and identical protein binding activity. Involved in estrous cycle. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in plasma membrane. Biomarker of pulmonary hypertension. Orthologous to human HAS1 (hyaluronan synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 15.6), Heart (RPKM 14.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (67366460..67378686, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (58693411..58705653, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (59720612..59732409, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hyaluronan synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronan synthase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to platelet-derived growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in extracellular matrix assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix assembly	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hyaluronan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in polysaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hyaluronan synthase 1

NP_758826.1

EC 2.4.1.212

XP_038958527.1

EC 2.4.1.212

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172323.2 → NP_758826.1 hyaluronan synthase 1

See identical proteins and their annotated locations for NP_758826.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

Q8CH93

Related

ENSRNOP00000014824.4, ENSRNOT00000014824.6

Conserved Domains (2) summary

TIGR04242
Location:51 → 493

nodulat_NodC; chitooligosaccharide synthase NodC

cl11394
Location:100 → 391

Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

67366460..67378686 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102599.2 → XP_038958527.1 hyaluronan synthase 1 isoform X1

Conserved Domains (1) summary

cl11394
Location:100 → 362

Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold