Uqcc3 ubiquinol-cytochrome c reductase complex assembly factor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uqcc3provided by RGD
Official Full Name: ubiquinol-cytochrome c reductase complex assembly factor 3provided by RGD
Primary source: RGD:1597344
See related: EnsemblRapid:ENSRNOG00000084496 AllianceGenome:RGD:1597344
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cardiolipin binding activity and phosphatidic acid binding activity. Predicted to be involved in cristae formation; mitochondrial electron transport, ubiquinol to cytochrome c; and mitochondrial respiratory chain complex III assembly. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 9. Orthologous to human UQCC3 (ubiquinol-cytochrome c reductase complex assembly factor 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 252.0), Adrenal (RPKM 223.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (215202700..215203478, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (205773591..205774369, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (225076301..225077079, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cardiolipin binding	ISO Inferred from Sequence Orthology more info
enables cardiolipin binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidic acid binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ATP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cristae formation	ISO Inferred from Sequence Orthology more info
involved_in cristae formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial respiratory chain complex III assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respiratory chain complex III assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex III assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: uncharacterized protein LOC690344

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.