Mrc2 mannose receptor, C type 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mrc2provided by RGD
Official Full Name: mannose receptor, C type 2provided by RGD
Primary source: RGD:1559436
See related: EnsemblRapid:ENSRNOG00000006548 AllianceGenome:RGD:1559436
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Endo180
Summary: Enables collagen binding activity. Predicted to be involved in collagen catabolic process. Predicted to be located in plasma membrane. Orthologous to human MRC2 (mannose receptor C-type 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 141.9), Uterus (RPKM 124.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (90761751..90823055)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (90261986..90323187)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (93520272..93581599)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endo180 binds to the C-terminal region of type I collagen, and this interaction appears to play an important role in cell-matrix adhesion
Title: Endo180 binds to the C-terminal region of type I collagen.

Submit: New GeneRIF Correction

General gene information

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Markers

BF396623 (e-PCR)
- UniSTS:245825

D10Got137 (e-PCR)
- UniSTS:114565

MARC_26180-26181:1030714398:1 (e-PCR)
- UniSTS:268973

AU047906 (e-PCR)
- UniSTS:110060

BF398330 (e-PCR)
- UniSTS:246765

RH128903 (e-PCR)
- UniSTS:212211

AU049984 (e-PCR)
- UniSTS:146426

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	IPI Inferred from Physical Interaction more info	PubMed
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IEA Inferred from Electronic Annotation more info
involved_in collagen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-type mannose receptor 2

Names: collagen-binding factor Endo180; endocytic receptor 180; macrophage mannose receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024687.2 → NP_001019858.2 C-type mannose receptor 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q4TU93

Related

ENSRNOP00000052010.3, ENSRNOT00000055137.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

90761751..90823055

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247631.5 → XP_006247693.1 C-type mannose receptor 2 isoform X1

UniProtKB/TrEMBL

A6HJX8, F1LMA7

Conserved Domains (5) summary

smart00059
Location:214 → 262

FN2; Fibronectin type 2 domain

cd00037
Location:281 → 395

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

smart00034
Location:416 → 539

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00458
Location:80 → 195

RICIN; Ricin-type beta-trefoil

cd00161
Location:77 → 161

RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...