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    Krt40 keratin 40 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287679, updated on 9-Dec-2024

    Summary

    Official Symbol
    Krt40provided by RGD
    Official Full Name
    keratin 40provided by RGD
    Primary source
    RGD:1359145
    See related
    EnsemblRapid:ENSRNOG00000013896 AllianceGenome:RGD:1359145
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ka36
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in epithelial cell differentiation and intermediate filament organization. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Orthologous to human KRT40 (keratin 40). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Krt40 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (84992720..84998898, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (84496470..84502756, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (87453624..87459670, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene keratin 23 Neighboring gene uncharacterized LOC108352133 Neighboring gene keratin 39 Neighboring gene keratin associated protein 3-3 Neighboring gene adenosine kinase, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    keratin, type I cytoskeletal 40
    Names
    CK-40
    K40
    cytokeratin-40
    keratin 40, type I
    type I hair keratin KA36

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008821.1NP_001008821.1  keratin, type I cytoskeletal 40

      See identical proteins and their annotated locations for NP_001008821.1

      Status: PROVISIONAL

      Source sequence(s)
      BK004036
      UniProtKB/Swiss-Prot
      Q6IFW2
      Related
      ENSRNOP00000018804.4, ENSRNOT00000018804.6
      Conserved Domains (1) summary
      pfam00038
      Location:88399
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      84992720..84998898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597133.3XP_017452622.1  keratin, type I cytoskeletal 40 isoform X1

      UniProtKB/TrEMBL
      A0A8I5XVJ4
      Related
      ENSRNOP00000076895.1, ENSRNOT00000104228.2