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    Tbccd1 TBCC domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303830, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tbccd1provided by RGD
    Official Full Name
    TBCC domain containing 1provided by RGD
    Primary source
    RGD:1309604
    See related
    EnsemblRapid:ENSRNOG00000026458 AllianceGenome:RGD:1309604
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Crygs
    Summary
    Predicted to be involved in several processes, including maintenance of Golgi location; maintenance of centrosome location; and regulation of cell shape. Predicted to be located in centrosome; cytoplasm; and spindle pole. Predicted to be active in spindle pole centrosome. Orthologous to human TBCCD1 (TBCC domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 76.1), Testes (RPKM 68.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbccd1 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (91672948..91710120)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (78168386..78205314)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (81757963..81794367)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene alpha-2-HS-glycoprotein Neighboring gene DnaJ heat shock protein family (Hsp40) member B11 Neighboring gene crystallin, gamma S Neighboring gene uncharacterized LOC100911962

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TBCCD1, a new centrosomal protein, is required for centrosome and Golgi apparatus positioning. Gonçalves J, et al. EMBO Rep, 2010 Mar. PMID 20168327, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108782

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in maintenance of Golgi location IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of Golgi location ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of Golgi location ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in maintenance of centrosome location IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of centrosome location ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of centrosome location ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle pole centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    TBCC domain-containing protein 1
    Names
    crystallin, gamma S

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012016.1 → NP_001012016.1  TBCC domain-containing protein 1

      See identical proteins and their annotated locations for NP_001012016.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089823
      UniProtKB/Swiss-Prot
      Q5FVR8
      UniProtKB/TrEMBL
      A0A8I5ZT70
      Related
      ENSRNOP00000088290.1, ENSRNOT00000111940.2
      Conserved Domains (1) summary
      pfam07986
      Location:329 → 444
      TBCC; Tubulin binding cofactor C

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      91672948..91710120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248545.5 → XP_006248607.1  TBCC domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZT70
      Related
      ENSRNOP00000036828.5, ENSRNOT00000038826.5
      Conserved Domains (1) summary
      pfam07986
      Location:362 → 477
      TBCC; Tubulin binding cofactor C

    2. XM_039088290.2 → XP_038944218.1  TBCC domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      Q6AXX8
      Conserved Domains (1) summary
      cl29757
      Location:362 → 407
      TBCC; Tubulin binding cofactor C

    3. XM_039088289.2 → XP_038944217.1  TBCC domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5FVR8
      UniProtKB/TrEMBL
      A0A8I5ZT70
      Conserved Domains (1) summary
      pfam07986
      Location:329 → 444
      TBCC; Tubulin binding cofactor C
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVR8.1 GenPept UniProtKB/Swiss-Prot:Q5FVR8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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