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    Oas1k 2 ' -5 ' oligoadenylate synthetase 1K [ Rattus norvegicus (Norway rat) ]

    Gene ID: 494198, updated on 9-Dec-2024

    Summary

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    Symbol
    Oas1kprovided by RGD
    Full Name
    2 ' -5 ' oligoadenylate synthetase 1Kprovided by RGD
    Primary source
    RGD:1359279
    See related
    EnsemblRapid:ENSRNOG00000062846 AllianceGenome:RGD:1359279
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 2'-5'-oligoadenylate synthetase activity. Predicted to be involved in defense response to virus and innate immune response. Predicted to be located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 54.4), Spleen (RPKM 39.0) and 9 other tissues See more
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    Genomic context

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    See Oas1k in Genome Data Viewer
    Location:
    12q16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41423100..41432330, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35762483..35771710, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41293803..41307352, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 2-5 oligoadenylate synthetase 1B Neighboring gene 2'-5' oligoadenylate synthetase 1E Neighboring gene 2'-5'-oligoadenylate synthetase 3 Neighboring gene 2'-5' oligoadenylate synthetase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla. Perelygin AA, et al. J Mol Evol, 2006 Oct. PMID 17024523
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2'-5'-oligoadenylate synthetase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2 ' -5 ' oligoadenylate synthetase 1K
    Names
    2'-5' oligoadenylate synthetase 1K

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009489.1 → NP_001009489.1  2 ' -5 ' oligoadenylate synthetase 1K

      See identical proteins and their annotated locations for NP_001009489.1

      Status: PROVISIONAL

      Source sequence(s)
      AY196696
      UniProtKB/TrEMBL
      F7FHW2, M0RA89, Q5MYX2
      Related
      ENSRNOP00000066431.3, ENSRNOT00000075317.5
      Conserved Domains (2) summary
      cd05400
      Location:27 → 210
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:162 → 346
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      41423100..41432330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249400.5 → XP_006249462.1  2 ' -5 ' oligoadenylate synthetase 1K isoform X1

      UniProtKB/TrEMBL
      D4A6M3, M0R9N6
      Related
      ENSRNOP00000066212.3, ENSRNOT00000075234.4
      Conserved Domains (2) summary
      cd05400
      Location:27 → 210
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:162 → 346
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    2. XM_039089658.2 → XP_038945586.1  2 ' -5 ' oligoadenylate synthetase 1K isoform X2

      Conserved Domains (2) summary
      cd05400
      Location:27 → 210
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:163 → 228
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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