Acmsd aminocarboxymuconate semialdehyde decarboxylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acmsdprovided by RGD
Official Full Name: aminocarboxymuconate semialdehyde decarboxylaseprovided by RGD
Primary source: RGD:620868
See related: EnsemblRapid:ENSRNOG00000003884 AllianceGenome:RGD:620868
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables aminocarboxymuconate-semialdehyde decarboxylase activity. Involved in tryptophan catabolic process. Predicted to be active in cytosol. Used to study kidney failure. Orthologous to human ACMSD (aminocarboxymuconate semialdehyde decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1055.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (41752894..41798427)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (39200412..39245954)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (44424689..44468734)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results provide the first evidence that alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) is associated with cholesterol metabolism, and ACMSD gene expression may be upregulated by sterol regulatory element-binding protein-2
Title: Regulation of rat hepatic α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase, a key enzyme in the tryptophan- NAD pathway, by dietary cholesterol and sterol regulatory element-binding protein-2.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aminocarboxymuconate-semialdehyde decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables aminocarboxymuconate-semialdehyde decarboxylase activity	IEA Inferred from Electronic Annotation more info
NOT enables aminocarboxymuconate-semialdehyde decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables aminocarboxymuconate-semialdehyde decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables aminocarboxymuconate-semialdehyde decarboxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of quinolinate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of quinolinate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of quinolinate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in secondary metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tryptophan catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Names: picolinate carboxylase

NP_599199.1

EC 4.1.1.45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.