C4bpb complement component 4 binding protein, beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C4bpbprovided by RGD
Official Full Name: complement component 4 binding protein, betaprovided by RGD
Primary source: RGD:2236
See related: EnsemblRapid:ENSRNOG00000004125 AllianceGenome:RGD:2236
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: C4bp-ps1
Summary: Predicted to be involved in several processes, including negative regulation of complement activation, classical pathway; regulation of opsonization; and response to symbiotic bacterium. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4BPB (complement component 4 binding protein beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 3188.9) See more
Orthologs: human all
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Genomic context

Location:: 13q13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (44673064..44683781, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (42120798..42131515, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (47387173..47398115, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH142451 (e-PCR)
- UniSTS:231698

RH130286 (e-PCR)
- UniSTS:213573

RH130340 (e-PCR)
- UniSTS:213624

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of complement activation, classical pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of opsonization	IEA Inferred from Electronic Annotation more info
involved_in regulation of opsonization	ISO Inferred from Sequence Orthology more info
involved_in response to symbiotic bacterium	IEA Inferred from Electronic Annotation more info
involved_in response to symbiotic bacterium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C4b-binding protein beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016995.2 → NP_058691.2 C4b-binding protein beta chain precursor

See identical proteins and their annotated locations for NP_058691.2

Status: PROVISIONAL

Source sequence(s)

BC088152

UniProtKB/Swiss-Prot

Q63515

UniProtKB/TrEMBL

A0A5C5, A6IBZ1, F7EP12

Related

ENSRNOP00000005505.3, ENSRNOT00000005505.6

Conserved Domains (1) summary

cd00033
Location:136 → 189

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system