Txk TXK tyrosine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Txkprovided by RGD
Official Full Name: TXK tyrosine kinaseprovided by RGD
Primary source: RGD:1306481
See related: EnsemblRapid:ENSRNOG00000025925 AllianceGenome:RGD:1306481
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including positive regulation of immune response; positive regulation of macromolecule biosynthetic process; and protein autophosphorylation. Predicted to act upstream of or within NK T cell differentiation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human TXK (TXK tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 104.8), Spleen (RPKM 80.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (35817270..35873454)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (35463369..35519448)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (38029809..38085822)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU048888 (e-PCR)
- UniSTS:145338

RH142374 (e-PCR)
- UniSTS:231621

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within NK T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein kinase TXK

NP_001019426.1

EC 2.7.10.1

XP_038947821.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024255.1 → NP_001019426.1 tyrosine-protein kinase TXK

See identical proteins and their annotated locations for NP_001019426.1

Status: PROVISIONAL

Source sequence(s)

BC095847

UniProtKB/TrEMBL

A0A8I5Y280, Q501W1

Related

ENSRNOP00000100194.1, ENSRNOT00000170168.1

Conserved Domains (4) summary

cd10398
Location:142 → 247

SH2_Tec_Txk; Src homology 2 (SH2) domain found in Tec protein, Txk

cd11907
Location:84 → 138

SH3_TXK; Src Homology 3 domain of TXK, also called Resting lymphocyte kinase (Rlk)

pfam07714
Location:270 → 519

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:265 → 520

PKc_like; Protein Kinases, catalytic domain