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    Irf9 interferon regulatory factor 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305896, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Irf9provided by RGD
    Official Full Name
    interferon regulatory factor 9provided by RGD
    Primary source
    RGD:1308766
    See related
    EnsemblRapid:ENSRNOG00000019478 AllianceGenome:RGD:1308766
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Isgf3g
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in immune system process and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol. Predicted to be part of ISGF3 complex. Predicted to be active in nucleus. Biomarker of acute pancreatitis and familial hyperlipidemia. Human ortholog(s) of this gene implicated in immunodeficiency 65. Orthologous to human IRF9 (interferon regulatory factor 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 190.9), Lung (RPKM 147.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Irf9 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33065422..33071881)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29095474..29101924)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34282936..34288981)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 2 Neighboring gene ring finger protein 31 Neighboring gene small ribosomal subunit protein uS19-like Neighboring gene REC8 meiotic recombination protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel function of IRF9 in acute pancreatitis by modulating cell apoptosis, proliferation, migration, and suppressing SIRT1-p53. Xue BH, et al. Mol Cell Biochem, 2020 Sep. PMID 32577948
    2. Negative Regulation of SIRT1 by IRF9 Involved in Hyperlipidemia Acute Pancreatitis Associated with Kidney Injury. Liu Y, et al. Dig Dis Sci, 2021 Apr. PMID 32462510
    3. Interferon regulatory factor 9 protects against cardiac hypertrophy by targeting myocardin. Jiang DS, et al. Hypertension, 2014 Jan. PMID 24144649
    4. PDGFR-β modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-κB pathway in subarachnoid hemorrhage rats. Wan W, et al. J Cereb Blood Flow Metab, 2019 Jul. PMID 29480757, Free PMC Article
    5. IRF9 Prevents CD8(+) T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection. Huber M, et al. J Virol, 2017 Nov 15. PMID 28878077, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel function of IRF9 in acute pancreatitis by modulating cell apoptosis, proliferation, migration, and suppressing SIRT1-p53.
      Title: A novel function of IRF9 in acute pancreatitis by modulating cell apoptosis, proliferation, migration, and suppressing SIRT1-p53.
    2. study shows that Platelet-derived growth factor receptor-beta/interferon regulatory factor 9/sirtuin 1/NF-kappaB signaling played a role in the vascular smooth muscle cell phenotypic transformation after subarachnoid hemorrhage
      Title: PDGFR-β modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-κB pathway in subarachnoid hemorrhage rats.
    3. IRF9 is a vascular injury-response molecule that promotes VSMC proliferation. IRF9 expression is upregulated during neointima formation.
      Title: Interferon regulatory factor 9 is critical for neointima formation following vascular injury.
    4. IRF9 mediated myocardial reperfusion injury
      Title: Interferon regulatory factor 9 is an essential mediator of heart dysfunction and cell death following myocardial ischemia/reperfusion injury.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ISGF3 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon regulatory factor 9
    Names
    interferon dependent positive acting transcription factor 3 gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012041.1 → NP_001012041.1  interferon regulatory factor 9

      See identical proteins and their annotated locations for NP_001012041.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079454
      UniProtKB/TrEMBL
      A0A8I5ZQE9, Q68FP4
      Related
      ENSRNOP00000080540.2, ENSRNOT00000108002.2
      Conserved Domains (2) summary
      pfam00605
      Location:11 → 115
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:210 → 374
      IRF-3; Interferon-regulatory factor 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      33065422..33071881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093300.2 → XP_038949228.1  interferon regulatory factor 9 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQE9, A6KH21, G3V8J4
      Conserved Domains (2) summary
      pfam00605
      Location:11 → 115
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:210 → 374
      IRF-3; Interferon-regulatory factor 3

    2. XM_008770679.3 → XP_008768901.1  interferon regulatory factor 9 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQE9
      Conserved Domains (2) summary
      pfam00605
      Location:37 → 141
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:236 → 400
      IRF-3; Interferon-regulatory factor 3

    3. XM_063274256.1 → XP_063130326.1  interferon regulatory factor 9 isoform X3

    4. XM_006251974.5 → XP_006252036.1  interferon regulatory factor 9 isoform X2

      See identical proteins and their annotated locations for XP_006252036.1

      UniProtKB/TrEMBL
      A0A8I5ZQE9, A6KH21, G3V8J4
      Conserved Domains (2) summary
      pfam00605
      Location:11 → 115
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:210 → 374
      IRF-3; Interferon-regulatory factor 3

    5. XM_006251975.3 → XP_006252037.1  interferon regulatory factor 9 isoform X2

      See identical proteins and their annotated locations for XP_006252037.1

      UniProtKB/TrEMBL
      A0A8I5ZQE9, A6KH21, G3V8J4
      Conserved Domains (2) summary
      pfam00605
      Location:11 → 115
      IRF; Interferon regulatory factor transcription factor
      pfam10401
      Location:210 → 374
      IRF-3; Interferon-regulatory factor 3
    Nucleotide Protein Strain
    Heading Accession and Version

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