Trim35 tripartite motif-containing 35 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trim35provided by RGD
Official Full Name: tripartite motif-containing 35provided by RGD
Primary source: RGD:1564642
See related: EnsemblRapid:ENSRNOG00000009449 AllianceGenome:RGD:1564642
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in defense response to symbiont; negative regulation of mitotic cell cycle; and positive regulation of apoptotic process. Predicted to act upstream of or within negative regulation of cell population proliferation and positive regulation of myeloid cell apoptotic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human TRIM35 (tripartite motif containing 35). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 853.9), Adrenal (RPKM 554.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (44669222..44685766)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (40493697..40510246)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (42960255..42976798)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AI102486 (e-PCR)
- UniSTS:261138

BI279698 (e-PCR)
- UniSTS:245018

RH143250 (e-PCR)
- UniSTS:232497

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of myeloid cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of myeloid cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in suppression of viral release by host	IEA Inferred from Electronic Annotation more info
involved_in suppression of viral release by host	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM35

Names: tripartite motif protein 35; tripartite motif-containing protein 35

NP_001020313.2

EC 2.3.2.27

XP_017455266.1

EC 2.3.2.27

XP_063130624.1

EC 2.3.2.27

XP_063130625.1

EC 2.3.2.27

XP_063130626.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025142.2 → NP_001020313.2 E3 ubiquitin-protein ligase TRIM35

See identical proteins and their annotated locations for NP_001020313.2

Status: PROVISIONAL

Source sequence(s)

BC085942, CB743135

UniProtKB/Swiss-Prot

Q4VBW2, Q5RKG6

UniProtKB/TrEMBL

A6K6M5, G3V769

Related

ENSRNOP00000096960.2, ENSRNOT00000113248.2

Conserved Domains (4) summary

cd00021
Location:113 → 151

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

cd00162
Location:35 → 76

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam13863
Location:198 → 261

DUF4200; Domain of unknown function (DUF4200)

cl02614
Location:317 → 503

SPRY; SPRY domain