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    Cby2 chibby family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498572, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cby2provided by RGD
    Official Full Name
    chibby family member 2provided by RGD
    Primary source
    RGD:1561044
    See related
    EnsemblRapid:ENSRNOG00000047413 AllianceGenome:RGD:1561044
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spert
    Summary
    Predicted to enable identical protein binding activity. Predicted to be located in cytoplasmic vesicle. Orthologous to human CBY2 (chibby family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 173.6) and Muscle (RPKM 5.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cby2 in Genome Data Viewer
    Location:
    15q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (57318820..57413687, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (50909435..51004449, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (57642576..57738383, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH type containing 13 Neighboring gene uncharacterized LOC120097040 Neighboring gene siah E3 ubiquitin protein ligase family member 3 Neighboring gene GABA type A receptor associated protein like 2, pseudogene 2 Neighboring gene glutamate-rich 6B Neighboring gene component of oligomeric golgi complex 3 Neighboring gene solute carrier family 25, member 30 Neighboring gene uncharacterized LOC102552389

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nurit, a novel leucine-zipper protein, expressed uniquely in the spermatid flower-like structure. Feige E, et al. Mech Dev, 2002 Sep. PMID 12204287
    2. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein chibby homolog 2
    Names
    spermatid associated
    spermatid-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017506.1 → NP_001017506.1  protein chibby homolog 2

      See identical proteins and their annotated locations for NP_001017506.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079300
      UniProtKB/Swiss-Prot
      Q6AXV6
      UniProtKB/TrEMBL
      A6HTT1
      Related
      ENSRNOP00000083970.2, ENSRNOT00000098900.2
      Conserved Domains (2) summary
      cd07429
      Location:76 → 191
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
      cl12007
      Location:366 → 425
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      57318820..57413687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770895.3 → XP_008769117.1  protein chibby homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_008769117.1

      UniProtKB/TrEMBL
      A0A8I6G3C8, A6HTT1
      Related
      ENSRNOP00000066296.2, ENSRNOT00000072138.3
      Conserved Domains (2) summary
      cd07429
      Location:61 → 176
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
      cl12007
      Location:351 → 410
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

    2. XM_008770893.4 → XP_008769115.1  protein chibby homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_008769115.1

      UniProtKB/TrEMBL
      A0A8I6G3C8, A6HTT1
      Conserved Domains (2) summary
      cd07429
      Location:61 → 176
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
      cl12007
      Location:351 → 410
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

    3. XM_006252329.4 → XP_006252391.1  protein chibby homolog 2 isoform X3

      UniProtKB/TrEMBL
      A6HTT1
      Conserved Domains (1) summary
      cl12007
      Location:1 → 116
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins

    4. XM_006252328.5 → XP_006252390.1  protein chibby homolog 2 isoform X2

      See identical proteins and their annotated locations for XP_006252390.1

      UniProtKB/TrEMBL
      A0A8I5ZY42, A6HTT0, A6HTT1
      Conserved Domains (2) summary
      cd07429
      Location:40 → 155
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
      cl12007
      Location:330 → 389
      Cby_like; Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXV6.1 GenPept UniProtKB/Swiss-Prot:Q6AXV6

    Gene LinkOut

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