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    Rreb1 ras responsive element binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306873, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rreb1provided by RGD
    Official Full Name
    ras responsive element binding protein 1provided by RGD
    Primary source
    RGD:1310904
    See related
    EnsemblRapid:ENSRNOG00000015701 AllianceGenome:RGD:1310904
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including positive regulation of brown fat cell differentiation; positive regulation of cell migration; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in fibrillar center and nuclear speck. Predicted to be active in nucleus. Orthologous to human RREB1 (ras responsive element binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 89.8), Kidney (RPKM 71.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rreb1 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (27082217..27208061, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (26876687..27002554, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (27539137..27718878, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097850 Neighboring gene uncharacterized LOC134482845 Neighboring gene cancer antigen 1 Neighboring gene signal sequence receptor subunit 1 Neighboring gene uncharacterized LOC134482846 Neighboring gene uncharacterized LOC100909970 Neighboring gene triosephosphate isomerase 1 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas. Thiagalingam A, et al. Mol Cell Biol, 1996 Oct. PMID 8816445, Free PMC Article
    2. Developmental silencing of human zeta-globin gene expression is mediated by the transcriptional repressor RREB1. Chen RL, et al. J Biol Chem, 2010 Apr 2. PMID 20133935, Free PMC Article
    3. Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway. Kent OA, et al. Genes Dev, 2010 Dec 15. PMID 21159816, Free PMC Article
    4. Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis. Brunmeir R, et al. PLoS Genet, 2016 Dec. PMID 27923061, Free PMC Article
    5. Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1. Melani M, et al. Curr Biol, 2008 Apr 8. PMID 18394891

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lamellipodium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mammary gland epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of wound healing, spreading of epidermal cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-responsive element-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107348.2 → NP_001100818.1  ras-responsive element-binding protein 1

      See identical proteins and their annotated locations for NP_001100818.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6J7B7, D3ZI11
      Related
      ENSRNOP00000056967.2, ENSRNOT00000060218.6
      Conserved Domains (4) summary
      COG5048
      Location:64 → 246
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:68 → 88
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1545 → 1567
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1531 → 1555
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      27082217..27208061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253814.5 → XP_006253876.1  ras-responsive element-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006253876.1

      UniProtKB/TrEMBL
      A0A0G2K4K0
      Related
      ENSRNOP00000073072.1, ENSRNOT00000079298.3
      Conserved Domains (4) summary
      COG5048
      Location:64 → 246
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:68 → 88
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1599 → 1621
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1585 → 1609
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006253817.4 → XP_006253879.1  ras-responsive element-binding protein 1 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:15 → 164
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:17 → 37
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1517 → 1539
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1503 → 1527
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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