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    Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246311, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pdp2provided by RGD
    Official Full Name
    pyruvate dehydrogenase phosphatase catalytic subunit 2provided by RGD
    Primary source
    RGD:628812
    See related
    EnsemblRapid:ENSRNOG00000012343 AllianceGenome:RGD:628812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity. Involved in peptidyl-threonine dephosphorylation and response to starvation. Located in mitochondrion. Orthologous to human PDP2 (pyruvate dehydrogenase phosphatase catalytic subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 376.4), Liver (RPKM 172.4) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Pdp2 in Genome Data Viewer
    Location:
    19p14
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (392858..400529, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (386408..394068, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (597427..601556, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene RRAD, Ras related glycolysis inhibitor and calcium channel regulator Neighboring gene cadherin 16 Neighboring gene uncharacterized LOC120098574 Neighboring gene uncharacterized LOC134483518 Neighboring gene carbonic anhydrase 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in T-helper cell differentiation  
    involved_in peptidyl-threonine dephosphorylation PubMed 
    involved_in response to starvation PubMed 
    involved_in signal transduction  
    Component Evidence Code Pubs
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial
    Names
    PDP 2
    PDPC 2
    pyruvate dehydrogenase phosphatase isoenzyme 2
    pyruvate dehyrogenase phosphatase catalytic subunit 2
    NP_659559.2
    XP_006255110.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145091.4NP_659559.2  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_659559.2

      Status: VALIDATED

      Source sequence(s)
      BC072485
      UniProtKB/Swiss-Prot
      A0A0G2JSL7, O88484, Q6IN27
      UniProtKB/TrEMBL
      A6JXU9
      Conserved Domains (1) summary
      smart00332
      Location:96516
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      392858..400529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255048.5XP_006255110.1  pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006255110.1

      UniProtKB/Swiss-Prot
      A0A0G2JSL7, O88484, Q6IN27
      UniProtKB/TrEMBL
      A6JXU9
      Related
      ENSRNOP00000112807.1, ENSRNOT00000156966.1
      Conserved Domains (1) summary
      smart00332
      Location:96516
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain
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