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    Galns galactosamine (N-acetyl)-6-sulfatase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292073, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Galnsprovided by RGD
    Official Full Name
    galactosamine (N-acetyl)-6-sulfataseprovided by RGD
    Primary source
    RGD:1565391
    See related
    EnsemblRapid:ENSRNOG00000014461 AllianceGenome:RGD:1565391
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable N-acetylgalactosamine-6-sulfatase activity and arylsulfatase activity. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in mucopolysaccharidosis IVA. Orthologous to human GALNS (galactosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 73.4), Lung (RPKM 47.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Galns in Genome Data Viewer
    Location:
    19q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (67537175..67570900, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (50628639..50662477, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (55391004..55423328, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene chromatin licensing and DNA replication factor 1 Neighboring gene adenine phosphoribosyl transferase Neighboring gene trafficking protein particle complex subunit 2L Neighboring gene PABPN1 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Treatment of skeletal and non-skeletal alterations of Mucopolysaccharidosis type IVA by AAV-mediated gene therapy. Bertolin J, et al. Nat Commun, 2021 Sep 9. PMID 34504088, Free PMC Article
    2. Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2. Zito E, et al. EMBO Rep, 2005 Jul. PMID 15962010, Free PMC Article
    3. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. Sardiello M, et al. Hum Mol Genet, 2005 Nov 1. PMID 16174644
    4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    5. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Treatment of skeletal and non-skeletal alterations of Mucopolysaccharidosis type IVA by AAV-mediated gene therapy.
      Title: Treatment of skeletal and non-skeletal alterations of Mucopolysaccharidosis type IVA by AAV-mediated gene therapy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetylgalactosamine-6-sulfatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylgalactosamine-6-sulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arylsulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfuric ester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylgalactosamine-6-sulfatase
    Names
    N-acetylgalactosamine-6-sulfate sulfatase
    chondroitinase
    chondroitinsulfatase
    galNAc6S sulfatase
    galactosamine (N-acetyl)-6-sulfate sulfatase
    galactose-6-sulfate sulfatase
    NP_001041316.1
    XP_017456734.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047851.3 → NP_001041316.1  N-acetylgalactosamine-6-sulfatase precursor

      See identical proteins and their annotated locations for NP_001041316.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q32KJ6
      UniProtKB/TrEMBL
      A6IZT2
      Related
      ENSRNOP00000019528.3, ENSRNOT00000019528.6
      Conserved Domains (1) summary
      cd16157
      Location:31 → 496
      GALNS; galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      67537175..67570900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601245.3 → XP_017456734.2  N-acetylgalactosamine-6-sulfatase isoform X1

    RNA

    1. XR_010059982.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q32KJ6.1 GenPept UniProtKB/Swiss-Prot:Q32KJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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