Selenbp1 selenium binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Selenbp1provided by RGD
Full Name: selenium binding protein 1provided by RGD
Primary source: RGD:620571
See related: EnsemblRapid:ENSRNOG00000047158 AllianceGenome:RGD:620571
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MTO; rSBP; Selenbp2
Summary: Predicted to enable methanethiol oxidase activity. Predicted to be involved in protein transport. Predicted to act upstream of or within brown fat cell differentiation. Predicted to be located in fibrillar center. Orthologous to human SELENBP1 (selenium binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: LOC103689947 appears to be a duplicate placement of Selenbp1 on Rnor_6.0 (Annot. Release 105) that is present on Rn_Celera but is absent from the previous reference assembly (Rnor_5.0) and not supported by syntenic regions in mouse and human. It appears that Selenbp1 was annotated on Rn_Celera as LOC103689947. Selenbp1 annotation on Rnor_6.0 is thus supported by annotation on Rn_Celera (as LOC103689947) and additionally, synteny with mouse and human. BLAST analysis of the LOC103689947 underlying component AABR07012460.1 shows 99% identity with a ~60 kb region of NC_005101.4 including where Selenbp1 is annotated. Annotation of Selenbp1 at this location on Rnor_6.0 is supported by annotation of LOC103689947 on Rn_Celera. This apparent duplication could be explained by misassembly of several underlying components on Rnor_6.0. [17 Mar 2015]
Expression: Biased expression in Kidney (RPKM 868.6), Lung (RPKM 835.5) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2q34

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (185183022..185193612)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (182494004..182504594)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (195416472..195423665, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SBP1 may play a critical role in the pathological processes underlying chemical-induced nephrotoxicity; urinary excretion of SBP1 might be a sensitive and specific biomarker to detect early stages of kidney injury.
Title: Selenium-binding protein 1: a sensitive urinary biomarker to detect heavy metal-induced nephrotoxicity.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables methanethiol oxidase activity	IEA Inferred from Electronic Annotation more info
enables methanethiol oxidase activity	ISO Inferred from Sequence Orthology more info
enables selenium binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: methanethiol oxidase

Names: 56 kDa selenium-binding protein; SBP56; SP56; selenium-binding protein 2

NP_001316822.1

EC 1.8.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001329893.1 → NP_001316822.1 methanethiol oxidase

Status: PROVISIONAL

Source sequence(s)

BC074008

UniProtKB/Swiss-Prot

Q8VIF7

UniProtKB/TrEMBL

A6K2T3

Related

ENSRNOP00000094007.1, ENSRNOT00000101667.2

Conserved Domains (1) summary

pfam05694
Location:7 → 472

SBP56; 56kDa selenium binding protein (SBP56)