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    Gabpb2 GA binding protein transcription factor subunit beta 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295263, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gabpb2provided by RGD
    Official Full Name
    GA binding protein transcription factor subunit beta 2provided by RGD
    Primary source
    RGD:1565234
    See related
    EnsemblRapid:ENSRNOG00000021105 AllianceGenome:RGD:1565234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565234
    Summary
    Predicted to enable identical protein binding activity and transcription cis-regulatory region binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human GABPB2 (GA binding protein transcription factor subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 100.2), Thymus (RPKM 91.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gabpb2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185444309..185484200, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182755304..182795368, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196357030..196392514, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene LysM domain containing 1 Neighboring gene TNF alpha induced protein 8 like 2 Neighboring gene uncharacterized LOC120100877 Neighboring gene semaphorin 6C Neighboring gene MLLT11, transcription factor 7 cofactor Neighboring gene CDC42 small effector 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals. Du K, et al. J Biol Chem, 1998 Dec 25. PMID 9857059
    2. Molecular and genetic characterization of GABP beta. de la Brousse FC, et al. Genes Dev, 1994 Aug 1. PMID 7958862
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GA binding protein transcription factor subunit beta 2; GA-binding protein subunit beta-2
    Names
    GA binding protein transcription factor, beta subunit 2
    GA repeat binding protein, beta 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433084.1 → NP_001420013.1  GA binding protein transcription factor subunit beta 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D3ZSD3

    2. NM_001433085.1 → NP_001420014.1  GA binding protein transcription factor subunit beta 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D3ZSD3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      185444309..185484200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232936.4 → XP_006232998.1  GA-binding protein subunit beta-2

      Conserved Domains (4) summary
      cd00204
      Location:34 → 156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:42 → 132
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]

    2. XM_227439.9 → XP_227439.6  GA-binding protein subunit beta-2

      Related
      ENSRNOP00000028661.5, ENSRNOT00000028661.9
      Conserved Domains (4) summary
      cd00204
      Location:34 → 156
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:42 → 132
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:10 → 58
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:38 → 68
      ANK; ANK repeat [structural motif]

    RNA

    1. XR_005501120.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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