Atat1 alpha tubulin acetyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atat1provided by RGD
Official Full Name: alpha tubulin acetyltransferase 1provided by RGD
Primary source: RGD:1303066
See related: EnsemblRapid:ENSRNOG00000000809 AllianceGenome:RGD:1303066
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TAT; Mec17; RGD1303066; 3110080J08Rik
Summary: Predicted to enable lysine N-acetyltransferase activity, acting on acetyl phosphate as donor and tubulin N-acetyltransferase activity. Predicted to be involved in several processes, including alpha-tubulin acetylation; response to mechanical stimulus; and response to pain. Predicted to act upstream of or within several processes, including dentate gyrus development; positive regulation of NLRP3 inflammasome complex assembly; and regulation of fat cell differentiation. Predicted to be located in Golgi apparatus; cytoskeleton; and cytosol. Predicted to be active in membrane. Orthologous to human ATAT1 (alpha tubulin acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 33.8), Testes (RPKM 29.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (2849399..2862614)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (2844595..2857809)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (3351269..3364565)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Eml1 promotes axonal growth by enhancing alphaTAT1-mediated microtubule acetylation.
Title: Eml1 promotes axonal growth by enhancing αTAT1-mediated microtubule acetylation.
HAGLR aggravates neuropathic pain and promotes inflammatory response and apoptosis of lipopolysaccharide-treated SH-SY5Y cells by sequestering miR-182-5p from ATAT1 and activating NLRP3 inflammasome.
Title: HAGLR aggravates neuropathic pain and promotes inflammatory response and apoptosis of lipopolysaccharide-treated SH-SY5Y cells by sequestering miR-182-5p from ATAT1 and activating NLRP3 inflammasome.
while alphaTAT1 may be important for axonal growth in vitro, neither alphaTAT1 nor HDAC5 had an effect in vivo on the regeneration of sciatic nerves.
Title: Effects of αTAT1 and HDAC5 on axonal regeneration in adult neurons.
These results agree with the hypothesis that the acetylation of alpha-tubulin by ATAT1 regulates the intracellular transport of secretory granules in corticotrophs.
Title: Adrenalectomy facilitates ATAT1 expression and α-tubulin acetylation in ACTH-producing corticotrophs.
These results indicated that alpha-tubulin acetylation by ATAT1 at distinct subcellular positions may influence the functional regulation of microtubules and cilia in a variety of ciliated cells.
Title: Intracellular localization of α-tubulin acetyltransferase ATAT1 in rat ciliated cells.
This finding reveals the importance of MEC-17 and alpha-tubulin acetylation in cortical development.
Title: MEC-17 deficiency leads to reduced α-tubulin acetylation and impaired migration of cortical neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

BE117058 (e-PCR)
- UniSTS:248640

AI548047 (e-PCR)
- UniSTS:260747

RH128043 (e-PCR)
- UniSTS:211351

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	IEA Inferred from Electronic Annotation more info
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISO Inferred from Sequence Orthology more info
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISS Inferred from Sequence or Structural Similarity more info
enables tubulin N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tubulin N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tubulin N-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in NLRP3 inflammasome complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within alpha-tubulin acetylation	ISO Inferred from Sequence Orthology more info
involved_in alpha-tubulin acetylation	ISO Inferred from Sequence Orthology more info
involved_in alpha-tubulin acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in dentate gyrus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dentate gyrus development	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in neuron development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of fat cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to pain	IEA Inferred from Electronic Annotation more info
involved_in response to pain	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
is_active_in membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule bundle	IEA Inferred from Electronic Annotation more info
located_in microtubule bundle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-tubulin N-acetyltransferase 1

Names: acetyltransferase mec-17 homolog; alpha-TAT; alpha-TAT1

NP_997663.1

EC 2.3.1.108

XP_006256012.1

EC 2.3.1.108

XP_006256013.1

EC 2.3.1.108

XP_038954724.1

EC 2.3.1.108

XP_038954725.1

EC 2.3.1.108

XP_063135270.1

EC 2.3.1.108

XP_063135271.1

EC 2.3.1.108

XP_063135272.1

EC 2.3.1.108

XP_063135273.1

EC 2.3.1.108

XP_063135274.1

EC 2.3.1.108

XP_063135275.1

EC 2.3.1.108

XP_063135276.1

EC 2.3.1.108

XP_063135277.1

EC 2.3.1.108

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212498.1 → NP_997663.1 alpha-tubulin N-acetyltransferase 1

See identical proteins and their annotated locations for NP_997663.1

Status: VALIDATED

Source sequence(s)

BX883048

UniProtKB/Swiss-Prot

Q6MG11

UniProtKB/TrEMBL

A0A8L2R8C1, A6KT73

Related

ENSRNOP00000098195.2, ENSRNOT00000120553.2

Conserved Domains (1) summary

pfam05301
Location:10 → 190

Acetyltransf_16; GNAT acetyltransferase, Mec-17

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

2849399..2862614

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279206.1 → XP_063135276.1 alpha-tubulin N-acetyltransferase 1 isoform X11

Related

ENSRNOP00000111683.1, ENSRNOT00000120554.2
XM_063279202.1 → XP_063135272.1 alpha-tubulin N-acetyltransferase 1 isoform X4

Related

ENSRNOP00000001065.6, ENSRNOT00000001065.8
XM_063279203.1 → XP_063135273.1 alpha-tubulin N-acetyltransferase 1 isoform X6
XM_039098797.2 → XP_038954725.1 alpha-tubulin N-acetyltransferase 1 isoform X5

UniProtKB/TrEMBL

A0A0G2K6T3, A0A0G2K9K5

Conserved Domains (1) summary

pfam05301
Location:10 → 190

Acetyltransf_16; GNAT acetyltransferase, Mec-17
XM_063279205.1 → XP_063135275.1 alpha-tubulin N-acetyltransferase 1 isoform X8
XM_063279200.1 → XP_063135270.1 alpha-tubulin N-acetyltransferase 1 isoform X2
XM_039098796.2 → XP_038954724.1 alpha-tubulin N-acetyltransferase 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K9K5, A6KT74

Conserved Domains (1) summary

pfam05301
Location:10 → 190

Acetyltransf_16; GNAT acetyltransferase, Mec-17
XM_063279204.1 → XP_063135274.1 alpha-tubulin N-acetyltransferase 1 isoform X7
XM_063279201.1 → XP_063135271.1 alpha-tubulin N-acetyltransferase 1 isoform X3

UniProtKB/TrEMBL

A0A8L2R8C1, G3V628

Related

ENSRNOP00000001077.5, ENSRNOT00000001077.9
XM_006255950.5 → XP_006256012.1 alpha-tubulin N-acetyltransferase 1 isoform X9

See identical proteins and their annotated locations for XP_006256012.1

UniProtKB/TrEMBL

A0A8I6A4A0, A6KT75

Related

ENSRNOP00000112539.1, ENSRNOT00000080158.4

Conserved Domains (1) summary

pfam05301
Location:79 → 190

Mec-17; Touch receptor neuron protein Mec-17
XM_006255951.5 → XP_006256013.1 alpha-tubulin N-acetyltransferase 1 isoform X10

Conserved Domains (1) summary

pfam05301
Location:10 → 190

Acetyltransf_16; GNAT acetyltransferase, Mec-17
XM_063279207.1 → XP_063135277.1 alpha-tubulin N-acetyltransferase 1 isoform X12

UniProtKB/TrEMBL

A6KT77