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    Tmprss3 transmembrane serine protease 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309665, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmprss3provided by RGD
    Official Full Name
    transmembrane serine protease 3provided by RGD
    Primary source
    RGD:1310135
    See related
    EnsemblRapid:ENSRNOG00000001165 AllianceGenome:RGD:1310135
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable sodium channel regulator activity. Predicted to be involved in sensory perception of sound. Predicted to act upstream of or within intracellular sodium ion homeostasis. Predicted to be located in endoplasmic reticulum membrane and neuronal cell body. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 8 and sensorineural hearing loss. Orthologous to human TMPRSS3 (transmembrane serine protease 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 6.5), Thymus (RPKM 4.8) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmprss3 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (9253497..9275167, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (9254102..9273808, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (9910522..9929705, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA44 Neighboring gene trefoil factor 1 Neighboring gene ubiquitin associated and SH3 domain containing, A Neighboring gene radial spoke head component 1 Neighboring gene solute carrier family 37 member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. [Expression of TMPRSS3 in the rat cochlea following kanamycin ototoxicity]. Peng A, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2011 Oct. PMID 22086001
    2. Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Iacobuzio-Donahue CA, et al. Cancer Res, 2003 Dec 15. PMID 14695172
    3. Tmprss3, a transmembrane serine protease deficient in human DFNB8/10 deafness, is critical for cochlear hair cell survival at the onset of hearing. Fasquelle L, et al. J Biol Chem, 2011 May 13. PMID 21454591, Free PMC Article
    4. Insertion of beta-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness. Scott HS, et al. Nat Genet, 2001 Jan. PMID 11137999
    5. The transmembrane serine protease (TMPRSS3) mutated in deafness DFNB8/10 activates the epithelial sodium channel (ENaC) in vitro. Guipponi M, et al. Hum Mol Genet, 2002 Nov 1. PMID 12393794

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular sodium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protease serine 3
    Names
    transmembrane protease, serine 3
    NP_001101089.1
    XP_038954650.1
    XP_038954651.1
    XP_038954652.1
    XP_038954653.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107619.1 → NP_001101089.1  transmembrane protease serine 3

      See identical proteins and their annotated locations for NP_001101089.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473988
      UniProtKB/TrEMBL
      A6JJZ0, D3ZY65
      Related
      ENSRNOP00000001540.6, ENSRNOT00000001540.7
      Conserved Domains (3) summary
      cd00112
      Location:74 → 107
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:217 → 446
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:112 → 211
      SRCR_2; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      9253497..9275167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098724.2 → XP_038954652.1  transmembrane protease serine 3 isoform X1

      UniProtKB/TrEMBL
      D3ZY65
      Conserved Domains (3) summary
      smart00020
      Location:216 → 444
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:74 → 107
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam15494
      Location:112 → 211
      SRCR_2; Scavenger receptor cysteine-rich domain

    2. XM_039098723.2 → XP_038954651.1  transmembrane protease serine 3 isoform X1

      UniProtKB/TrEMBL
      D3ZY65
      Conserved Domains (3) summary
      smart00020
      Location:216 → 444
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:74 → 107
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam15494
      Location:112 → 211
      SRCR_2; Scavenger receptor cysteine-rich domain

    3. XM_039098722.2 → XP_038954650.1  transmembrane protease serine 3 isoform X1

      UniProtKB/TrEMBL
      D3ZY65
      Conserved Domains (3) summary
      smart00020
      Location:216 → 444
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:74 → 107
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam15494
      Location:112 → 211
      SRCR_2; Scavenger receptor cysteine-rich domain

    4. XM_039098725.2 → XP_038954653.1  transmembrane protease serine 3 isoform X2

      UniProtKB/TrEMBL
      A6JJZ0, D3ZY65
      Conserved Domains (3) summary
      cd00112
      Location:74 → 107
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:217 → 446
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:112 → 211
      SRCR_2; Scavenger receptor cysteine-rich domain
    Nucleotide Protein Strain
    Heading Accession and Version

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