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    Rtkn2 rhotekin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309729, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rtkn2provided by RGD
    Official Full Name
    rhotekin 2provided by RGD
    Primary source
    RGD:1304834
    See related
    EnsemblRapid:ENSRNOG00000067849 AllianceGenome:RGD:1304834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Plekhk1
    Summary
    Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of cell population proliferation; and regulation of intracellular signal transduction. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Orthologous to human RTKN2 (rhotekin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 291.9) and Thymus (RPKM 22.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rtkn2 in Genome Data Viewer
    Location:
    20p11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (20535553..20608863, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (20536628..20609951, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (21919486..22004279, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene AT-rich interaction domain 5B Neighboring gene uncharacterized LOC134483791 Neighboring gene uncharacterized LOC108349057 Neighboring gene uncharacterized LOC102550601 Neighboring gene uncharacterized LOC120098810 Neighboring gene uncharacterized LOC134483792 Neighboring gene uncharacterized LOC120098914 Neighboring gene uncharacterized LOC120098912

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RTKN2 Induces NF-KappaB Dependent Resistance to Intrinsic Apoptosis in HEK Cells and Regulates BCL-2 Genes in Human CD4(+) Lymphocytes. Collier FM, et al. J Cell Death, 2009. PMID 26124677, Free PMC Article
    2. Identification and characterization of a lymphocytic Rho-GTPase effector: rhotekin-2. Collier FM, et al. Biochem Biophys Res Commun, 2004 Nov 26. PMID 15504364
    3. Genetic approach and phenotype-based complementation screening for identification of stroma cell-derived proteins involved in cell proliferation. Tulin EE, et al. Exp Cell Res, 2002 Jan 1. PMID 11740862
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in hemopoiesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rhotekin-2
    Names
    pleckstrin homology domain containing, family K member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107625.3 → NP_001101095.2  rhotekin-2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I5ZWM2, A0A8I6APU0
      Related
      ENSRNOP00000096702.1, ENSRNOT00000118813.2
      Conserved Domains (2) summary
      smart00742
      Location:12 → 67
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:280 → 389
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      20535553..20608863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256367.5 → XP_006256429.1  rhotekin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWM2
      Related
      ENSRNOP00000072047.3, ENSRNOT00000086250.3
      Conserved Domains (4) summary
      smart00742
      Location:12 → 67
      Hr1; Rho effector or protein kinase C-related kinase homology region 1 homologues
      cd13249
      Location:277 → 386
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam00169
      Location:282 → 380
      PH; PH domain
      pfam08174
      Location:90 → 238
      Anillin; Cell division protein anillin

    2. XM_039098751.2 → XP_038954679.1  rhotekin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZWM2
      Conserved Domains (2) summary
      cd13249
      Location:174 → 283
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
      pfam08174
      Location:1 → 135
      Anillin; Cell division protein anillin

    3. XM_039098754.2 → XP_038954682.1  rhotekin-2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K1Z6, A6JKV0, D3ZK83
      Conserved Domains (1) summary
      cd13249
      Location:3 → 112
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain

    4. XM_039098753.2 → XP_038954681.1  rhotekin-2 isoform X3

      Conserved Domains (1) summary
      cd13249
      Location:58 → 167
      PH_rhotekin2; Anillin Pleckstrin homology (PH) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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