Lrp1b LDL receptor related protein 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Lrp1bprovided by RGD
Full Name: LDL receptor related protein 1Bprovided by RGD
Primary source: RGD:1306160
See related: EnsemblRapid:ENSRNOG00000030243 AllianceGenome:RGD:1306160
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AABR07051892.1
Summary: Predicted to enable low-density lipoprotein particle receptor activity. Involved in response to organic cyclic compound. Predicted to be located in membrane. Predicted to be part of receptor complex. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung disease (multiple); and melanoma. Orthologous to human LRP1B (LDL receptor related protein 1B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 141.8), Adrenal (RPKM 18.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 3q12

Exon count:: 92

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (45004001..47125147, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (24594302..26715037, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (25201194..27348126, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity
Title: C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity.

Submit: New GeneRIF Correction

General gene information

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Markers

D3Mco16 (e-PCR)
- UniSTS:239910

D3Got19 (e-PCR)
- UniSTS:115239

RH138426 (e-PCR)
- UniSTS:220513

RH138233 (e-PCR)
- UniSTS:220320

BE121112 (e-PCR)
- UniSTS:248021

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables low-density lipoprotein particle receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	HEP more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: low-density lipoprotein receptor-related protein 1B

Names: low density lipoprotein-related protein 1B (deleted in tumors)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

45004001..47125147 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284873.1 → XP_063140943.1 low-density lipoprotein receptor-related protein 1B isoform X5

UniProtKB/TrEMBL

A0A8I6AQY2
XM_063284870.1 → XP_063140940.1 low-density lipoprotein receptor-related protein 1B isoform X2

UniProtKB/TrEMBL

A0A8I6AQY2
XM_063284872.1 → XP_063140942.1 low-density lipoprotein receptor-related protein 1B isoform X4

UniProtKB/TrEMBL

A0A8I6AQY2

Related

ENSRNOP00000047160.6, ENSRNOT00000044209.6
XM_063284871.1 → XP_063140941.1 low-density lipoprotein receptor-related protein 1B isoform X3

UniProtKB/TrEMBL

F1M443
XM_039106103.2 → XP_038962031.2 low-density lipoprotein receptor-related protein 1B isoform X1

UniProtKB/TrEMBL

A0A8I6AQY2

RNA

XR_010064783.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107843.1: Suppressed sequence

Description

NM_001107843.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: LRP1B (GeneID:53353).