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    Nat10 N-acetyltransferase 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311257, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nat10provided by RGD
    Official Full Name
    N-acetyltransferase 10provided by RGD
    Primary source
    RGD:1306717
    See related
    EnsemblRapid:ENSRNOG00000008663 AllianceGenome:RGD:1306717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306717
    Summary
    Predicted to enable DNA polymerase binding activity; N-acetyltransferase activity; and tRNA binding activity. Predicted to be involved in several processes, including rRNA acetylation involved in maturation of SSU-rRNA; regulation of centrosome duplication; and regulation of macromolecule biosynthetic process. Predicted to be located in midbody. Predicted to be part of small-subunit processome and telomerase holoenzyme complex. Predicted to be active in nucleolus. Orthologous to human NAT10 (N-acetyltransferase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 73.4), Thymus (RPKM 68.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nat10 in Genome Data Viewer
    Location:
    3q32
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (110566582..110604829, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (90111643..90149891, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (93658119..93698136, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101613 Neighboring gene uncharacterized LOC120101612 Neighboring gene ankyrin repeat and BTB domain containing 2 Neighboring gene cell cycle associated protein 1 Neighboring gene uncharacterized LOC120101611 Neighboring gene uncharacterized LOC134486415

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Acetylation of Cytidine in mRNA Promotes Translation Efficiency. Arango D, et al. Cell, 2018 Dec 13. PMID 30449621, Free PMC Article
    2. Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA). Ito S, et al. J Biol Chem, 2014 Dec 26. PMID 25411247, Free PMC Article
    3. NAT10-mediated ac(4)C acetylation of TFRC promotes sepsis-induced pulmonary injury through regulating ferroptosis. Xing P, et al. Mol Med, 2024 Sep 9. PMID 39251905, Free PMC Article
    4. NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis. Liu D, et al. Ann Rheum Dis, 2024 Aug 27. PMID 38724075
    5. Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1. Sharma S, et al. Nucleic Acids Res, 2015 Feb 27. PMID 25653167, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NAT10-mediated ac[4]C acetylation of TFRC promotes sepsis-induced pulmonary injury through regulating ferroptosis.
      Title: NAT10-mediated ac(4)C acetylation of TFRC promotes sepsis-induced pulmonary injury through regulating ferroptosis.
    2. NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis.
      Title: NAT10 promotes synovial aggression by increasing the stability and translation of N4-acetylated PTX3 mRNA in rheumatoid arthritis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables rRNA cytidine N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA acetylation involved in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble cytosine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA cytidine acetyltransferase
    Names
    N-acetyltransferase 10 (GCN5-related)
    NP_001386441.1
    XP_038960856.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399512.1 → NP_001386441.1  RNA cytidine acetyltransferase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HNS0, B5DFI0, G3V752
      Related
      ENSRNOP00000012094.3, ENSRNOT00000012094.7
      Conserved Domains (1) summary
      COG1444
      Location:20 → 901
      TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      110566582..110604829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104928.2 → XP_038960856.1  RNA cytidine acetyltransferase isoform X1

      UniProtKB/TrEMBL
      A6HNS0, B5DFI0, G3V752
      Conserved Domains (1) summary
      COG1444
      Location:20 → 901
      TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107756.1: Suppressed sequence

      Description
      NM_001107756.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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