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    Lzts3 leucine zipper tumor suppressor family member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 280670, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lzts3provided by RGD
    Official Full Name
    leucine zipper tumor suppressor family member 3provided by RGD
    Primary source
    RGD:631327
    See related
    EnsemblRapid:ENSRNOG00000021231 AllianceGenome:RGD:631327
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prosapip1
    Summary
    Enables PDZ domain binding activity. Involved in protein homooligomerization; regulation of dendritic spine morphogenesis; and regulation of postsynapse assembly. Located in dendritic spine. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human LZTS3 (leucine zipper tumor suppressor family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 173.9), Brain (RPKM 106.4) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lzts3 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138303378..138313645, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (117850286..117861132, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123174444..123185649, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene arginine vasopressin Neighboring gene U-box domain containing 5 Neighboring gene FAST kinase domains 5 Neighboring gene DDRGK domain containing 1 Neighboring gene inosine triphosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Shank3 Interaction Partner ProSAPiP1 Regulates Postsynaptic SPAR Levels and the Maturation of Dendritic Spines in Hippocampal Neurons. Reim D, et al. Front Synaptic Neurosci, 2016. PMID 27252646, Free PMC Article
    2. Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3. Dolnik A, et al. J Neurochem, 2016 Jan. PMID 26364583
    3. Secretory granules of hypophyseal and pancreatic endocrine cells contain proteins of the neuronal postsynaptic density. Redecker P, et al. Cell Tissue Res, 2007 Apr. PMID 17120053
    4. ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3. Wendholt D, et al. J Biol Chem, 2006 May 12. PMID 16522626
    5. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Bouwmeester T, et al. Nat Cell Biol, 2004 Feb. PMID 14743216

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Postsynaptic proteins, including ProSAPiP1/Lzts3, interacts with Sipa1L/SPAR3 in brain and is localized to excitatory postsynapses.
      Title: Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3.
    2. ProSAP/Shank and certain ProSAP/Shank-interacting proteins exhibit distinct subcellular localizations in the different cell types, raising the possibility that the function of ProSAP/Shank proteins is more diverse than has been envisaged to date.
      Title: Secretory granules of hypophyseal and pancreatic endocrine cells contain proteins of the neuronal postsynaptic density.
    3. A novel binding partner for the PDZ domain of SPAR and Shank3 proteins, ProSAPiP1, is reported and characterized.
      Title: ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein homooligomerization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of dendritic spine morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine zipper putative tumor suppressor 3
    Names
    leucine zipper, putative tumor suppressor family member 3
    proSAP-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172022.3 → NP_742019.3  leucine zipper putative tumor suppressor 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q8K1Q4
      UniProtKB/TrEMBL
      A6HQA4
      Related
      ENSRNOP00000110375.1, ENSRNOT00000150128.1
      Conserved Domains (2) summary
      COG1196
      Location:348 → 542
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:468 → 668
      Fez1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      138303378..138313645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235009.5 → XP_006235071.1  leucine zipper putative tumor suppressor 3 isoform X4

      See identical proteins and their annotated locations for XP_006235071.1

      UniProtKB/Swiss-Prot
      Q8K1Q4
      UniProtKB/TrEMBL
      G3V8V8
      Conserved Domains (2) summary
      pfam06818
      Location:484 → 683
      Fez1; Fez1
      pfam13863
      Location:376 → 478
      DUF4200; Domain of unknown function (DUF4200)

    2. XM_008762149.4 → XP_008760371.1  leucine zipper putative tumor suppressor 3 isoform X2

      UniProtKB/Swiss-Prot
      Q8K1Q4
      Related
      ENSRNOP00000028835.4, ENSRNOT00000028835.5
      Conserved Domains (1) summary
      pfam06818
      Location:514 → 709
      Fez1; Fez1

    3. XM_008762150.4 → XP_008760372.1  leucine zipper putative tumor suppressor 3 isoform X3

      UniProtKB/Swiss-Prot
      Q8K1Q4
      Related
      ENSRNOP00000084706.2, ENSRNOT00000101454.2
      Conserved Domains (1) summary
      pfam06818
      Location:498 → 693
      Fez1; Fez1

    4. XM_008762148.4 → XP_008760370.1  leucine zipper putative tumor suppressor 3 isoform X1

      UniProtKB/Swiss-Prot
      Q8K1Q4
      UniProtKB/TrEMBL
      A0A8I5ZYI8
      Conserved Domains (2) summary
      pfam06818
      Location:515 → 714
      Fez1; Fez1
      pfam13863
      Location:407 → 509
      DUF4200; Domain of unknown function (DUF4200)

    5. XM_006235014.4 → XP_006235076.1  leucine zipper putative tumor suppressor 3 isoform X5

      See identical proteins and their annotated locations for XP_006235076.1

      UniProtKB/Swiss-Prot
      Q8K1Q4
      Conserved Domains (2) summary
      COG1196
      Location:318 → 512
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:438 → 638
      Fez1

    6. XM_039104399.1 → XP_038960327.1  leucine zipper putative tumor suppressor 3 isoform X5

      UniProtKB/Swiss-Prot
      Q8K1Q4
      Conserved Domains (2) summary
      COG1196
      Location:318 → 512
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:438 → 638
      Fez1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1Q4.2 GenPept UniProtKB/Swiss-Prot:Q8K1Q4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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