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    Retsat retinol saturase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246298, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Retsatprovided by RGD
    Official Full Name
    retinol saturaseprovided by RGD
    Primary source
    RGD:628802
    See related
    EnsemblRapid:ENSRNOG00000014090 AllianceGenome:RGD:628802
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rmt7
    Summary
    Predicted to enable all-trans-retinol 13,14-reductase activity. Predicted to be involved in retinol metabolic process. Predicted to be located in nuclear outer membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human RETSAT (retinol saturase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1579.4), Adrenal (RPKM 1173.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Retsat in Genome Data Viewer
    Location:
    4q32
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (106211459..106220222)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (104653306..104662069)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (100465365..100474128)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 74 Neighboring gene capping actin protein, gelsolin like Neighboring gene ELMO domain containing 3 Neighboring gene trans-golgi network protein 2 Neighboring gene uncharacterized LOC102549526 Neighboring gene transcription factor 7 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Altered gene expression profile in chemically induced rat mammary adenocarcinomas and its modulation by an aromatase inhibitor. Wang Y, et al. Oncogene, 2001 Nov 22. PMID 11753649
    2. Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. Moise AR, et al. J Biol Chem, 2004 Nov 26. PMID 15358783, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables all-trans-retinol 13,14-reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans-retinol 13,14-reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables all-trans-retinol 13,14-reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables all-trans-retinol 13,14-reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nuclear outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    all-trans-retinol 13,14-reductase
    Names
    PPAR-alpha-regulated and starvation-induced gene protein
    RMT-7
    all-trans-13,14-dihydroretinol saturase
    hypothetical protein RMT-7
    retinol saturase (all trans retinol 13,14 reductase)
    NP_659552.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145084.1 → NP_659552.1  all-trans-retinol 13,14-reductase precursor

      See identical proteins and their annotated locations for NP_659552.1

      Status: PROVISIONAL

      Source sequence(s)
      AF465614
      UniProtKB/Swiss-Prot
      Q8VHE9
      UniProtKB/TrEMBL
      A0A8I6A1R3, A6IAD0
      Related
      ENSRNOP00000084674.1, ENSRNOT00000111459.2
      Conserved Domains (3) summary
      COG0446
      Location:25 → 103
      FadH2; NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism]
      COG1233
      Location:68 → 566
      COG1233; Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism]
      cl21454
      Location:68 → 568
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      106211459..106220222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHE9.1 GenPept UniProtKB/Swiss-Prot:Q8VHE9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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