Bcl2l13 Bcl2-like 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bcl2l13provided by RGD
Official Full Name: Bcl2-like 13provided by RGD
Primary source: RGD:1306985
See related: EnsemblRapid:ENSRNOG00000012394 AllianceGenome:RGD:1306985
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in apoptotic process and regulation of apoptotic process. Predicted to be located in mitochondrion. Predicted to be active in membrane. Orthologous to human BCL2L13 (BCL2 like 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 190.4), Muscle (RPKM 184.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (155728284..155785058)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (154056116..154112890)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (153385200..153438096)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-874-3p attenuated ischemic injury by negatively regulating BMF and BCL2L13.
Title: Upregulation of miR-874-3p decreases cerebral ischemia/reperfusion injury by directly targeting BMF and BCL2L13.

Submit: New GeneRIF Correction

General gene information

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Markers

RH129071 (e-PCR)
- UniSTS:212379

AU049146 (e-PCR)
- UniSTS:145594

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in canonical glycolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within canonical glycolysis	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitophagy	ISO Inferred from Sequence Orthology more info
involved_in oxidative phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bcl-2-like protein 13

Names: BCL2-like 13 (apoptosis facilitator)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398849.1 → NP_001385778.1 bcl-2-like protein 13

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I6ABQ2, D3ZT71

Related

ENSRNOP00000016561.6, ENSRNOT00000016561.9

Conserved Domains (1) summary

pfam00452
Location:104 → 200

Bcl-2; Apoptosis regulator proteins, Bcl-2 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

155728284..155785058

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286121.1 → XP_063142191.1 bcl-2-like protein 13 isoform X2
XM_063286122.1 → XP_063142192.1 bcl-2-like protein 13 isoform X3
XM_063286120.1 → XP_063142190.1 bcl-2-like protein 13 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107885.1: Suppressed sequence

Description

NM_001107885.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein