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    Tln1 talin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313494, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tln1provided by RGD
    Official Full Name
    talin 1provided by RGD
    Primary source
    RGD:1306247
    See related
    EnsemblRapid:ENSRNOG00000016630 AllianceGenome:RGD:1306247
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tln
    Summary
    Enables integrin binding activity. Predicted to be involved in several processes, including integrin activation; integrin-mediated signaling pathway; and platelet aggregation. Predicted to act upstream of or within cell-substrate junction assembly and cortical actin cytoskeleton organization. Predicted to be located in adherens junction. Predicted to be active in cytoplasm; focal adhesion; and plasma membrane. Orthologous to human TLN1 (talin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 810.5), Lung (RPKM 605.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tln1 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    58
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (62583730..62613687, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (57787670..57817900, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (59033635..59063592, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 9 Neighboring gene tropomyosin 2 Neighboring gene uncharacterized LOC134486933 Neighboring gene cAMP responsive element binding protein 3 Neighboring gene glucosylceramidase beta 2 Neighboring gene RGP1 homolog, RAB6A GEF complex partner 1 Neighboring gene microseminoprotein, prostate associated

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC116305

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables LIM domain binding  
    enables actin filament binding  
    enables integrin binding  
    enables integrin binding PubMed 
    enables integrin binding  
    enables phosphatidylinositol binding  
    enables phosphatidylserine binding  
    enables structural constituent of cytoskeleton  
    enables vinculin binding  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization  
    involved_in biological_process  
    involved_in cell-cell adhesion  
    acts_upstream_of_or_within cell-substrate junction assembly  
    acts_upstream_of_or_within cortical actin cytoskeleton organization  
    involved_in cortical microtubule organization  
    involved_in cortical microtubule organization  
    involved_in integrin activation  
    involved_in integrin-mediated signaling pathway  
    involved_in platelet aggregation PubMed 
    Component Evidence Code Pubs
    located_in adherens junction  
    is_active_in cytoplasm  
    located_in cytoskeleton  
    is_active_in focal adhesion  
    located_in focal adhesion  
    is_active_in plasma membrane  
    located_in ruffle  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039025.2NP_001034114.2  talin-1

      See identical proteins and their annotated locations for NP_001034114.2

      Status: PROVISIONAL

      Source sequence(s)
      CH473962
      UniProtKB/TrEMBL
      A6IJ31, A6IJ32, G3V852
      Related
      ENSRNOP00000022401.6, ENSRNOT00000022400.7
      Conserved Domains (10) summary
      cd12150
      Location:16541826
      talin-RS; rod-segment of the talin C-terminal domain
      smart00295
      Location:88313
      B41; Band 4.1 homologues
      smart00307
      Location:23362532
      ILWEQ; I/LWEQ domain
      cd10569
      Location:309400
      FERM_C_Talin; FERM domain C-lobe/F3 of Talin
      pfam00373
      Location:204313
      FERM_M; FERM central domain
      pfam08913
      Location:18491973
      VBS; Vinculin Binding Site
      pfam09141
      Location:491652
      Talin_middle; Talin, middle domain
      pfam09379
      Location:90186
      FERM_N; FERM N-terminal domain
      pfam16511
      Location:483
      FERM_f0; N-terminal or F0 domain of Talin-head FERM
      cl19756
      Location:822912
      I_LWEQ; I/LWEQ domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      62583730..62613687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287730.1XP_063143800.1  talin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABG6, A6IJ31
      Related
      ENSRNOP00000089335.1, ENSRNOT00000107665.2
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