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    Cdkl1 cyclin dependent kinase like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314198, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdkl1provided by RGD
    Official Full Name
    cyclin dependent kinase like 1provided by RGD
    Primary source
    RGD:1305080
    See related
    EnsemblRapid:ENSRNOG00000038720 AllianceGenome:RGD:1305080
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in heart development. Predicted to be located in ciliary transition zone and nucleoplasm. Predicted to be active in nucleus. Orthologous to human CDKL1 (cyclin dependent kinase like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 602.0) and Brain (RPKM 34.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdkl1 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (93960157..94005207, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (88224154..88273434, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (92076247..92123108, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene distal membrane arm assembly component 2 like Neighboring gene uncharacterized LOC102548655 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 5 Neighboring gene atlastin GTPase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of second messenger- and cyclin-dependent protein kinases during postnatal development of rat heart. Kim SO, et al. J Cell Biochem, 1998 Jun 15. PMID 9620176
    2. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heart development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary transition zone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase-like 1
    Names
    cyclin-dependent kinase-like 1 (CDC2-related kinase)
    NP_001020292.1
    XP_006240235.1
    XP_038968181.1
    XP_038968182.1
    XP_038968183.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025121.1 → NP_001020292.1  cyclin-dependent kinase-like 1

      See identical proteins and their annotated locations for NP_001020292.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081896
      UniProtKB/Swiss-Prot
      Q66HE7
      UniProtKB/TrEMBL
      A0A8L2UHZ3, A6HBX5
      Related
      ENSRNOP00000006374.7, ENSRNOT00000006374.7
      Conserved Domains (2) summary
      cd07847
      Location:2 → 287
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4
      pfam00069
      Location:4 → 287
      Pkinase; Protein kinase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      93960157..94005207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112254.2 → XP_038968182.1  cyclin-dependent kinase-like 1 isoform X2

      Conserved Domains (1) summary
      cd07847
      Location:2 → 287
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    2. XM_039112253.2 → XP_038968181.1  cyclin-dependent kinase-like 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GJE5
      Related
      ENSRNOP00000092011.1, ENSRNOT00000103862.2
      Conserved Domains (1) summary
      cd07847
      Location:2 → 287
      STKc_CDKL1_4; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4

    3. XM_006240173.5 → XP_006240235.1  cyclin-dependent kinase-like 1 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:66 → 232
      PKc_like; Protein Kinases, catalytic domain

    4. XM_039112255.2 → XP_038968183.1  cyclin-dependent kinase-like 1 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:2 → 220
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HE7.1 GenPept UniProtKB/Swiss-Prot:Q66HE7

    Gene LinkOut

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