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    Tmprss5 transmembrane serine protease 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266681, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmprss5provided by RGD
    Official Full Name
    transmembrane serine protease 5provided by RGD
    Primary source
    RGD:628625
    See related
    EnsemblRapid:ENSRNOG00000008058 AllianceGenome:RGD:628625
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Amp
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in neuronal cell body. Predicted to be active in plasma membrane. Orthologous to human TMPRSS5 (transmembrane serine protease 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 34.8), Muscle (RPKM 16.4) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmprss5 in Genome Data Viewer
    Location:
    8q23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (58338455..58357886)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (49437321..49461395)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (53411259..53430744)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene claudin 25 Neighboring gene zw10 kinetochore protein Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134480049 Neighboring gene uncharacterized LOC134480047

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of two alternate splice variants of a novel serine protease expressed in steroidogenic tissues. Omer S, et al. Endocr Res, 2002 Nov. PMID 12530635
    2. An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss. Guipponi M, et al. Hum Mutat, 2008 Jan. PMID 17918732
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AmP-Long has no effect on steroidogenesis nor cleaves StAR as was shown by western blot analysis using StAR antibody.
      Title: Identification of two alternate splice variants of a novel serine protease expressed in steroidogenic tissues.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protease serine 5
    Names
    adrenal mitochondrial protease
    transmembrane protease, serine 5 (spinesin)
    NP_695223.2
    XP_038936856.1
    XP_038936857.1
    XP_063121060.1
    XP_063121061.1
    XP_063121062.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153311.2 → NP_695223.2  transmembrane protease serine 5

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J4B2, Q8CJ17
      Related
      ENSRNOP00000011107.7, ENSRNOT00000011107.9
      Conserved Domains (2) summary
      cd00190
      Location:208 → 441
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:106 → 203
      SRCR_2; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      58338455..58357886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264990.1 → XP_063121060.1  transmembrane protease serine 5 isoform X1

      UniProtKB/TrEMBL
      Q8CJ17

    2. XM_063264992.1 → XP_063121062.1  transmembrane protease serine 5 isoform X4

    3. XM_063264991.1 → XP_063121061.1  transmembrane protease serine 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A2F3, A6J4B4

    4. XM_039080928.2 → XP_038936856.1  transmembrane protease serine 5 isoform X3

      UniProtKB/TrEMBL
      A6J4B4
      Conserved Domains (2) summary
      cd00190
      Location:150 → 383
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:48 → 145
      SRCR_2; Scavenger receptor cysteine-rich domain

    5. XM_039080929.2 → XP_038936857.1  transmembrane protease serine 5 isoform X5

      UniProtKB/TrEMBL
      A6J4B4
      Conserved Domains (2) summary
      cd00190
      Location:74 → 307
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:3 → 69
      SRCR_2; Scavenger receptor cysteine-rich domain
    Nucleotide Protein Strain
    Heading Accession and Version

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