Rplp1 ribosomal protein lateral stalk subunit P1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rplp1provided by RGD
Official Full Name: ribosomal protein lateral stalk subunit P1provided by RGD
Primary source: RGD:621774
See related: EnsemblRapid:ENSRNOG00000054840 AllianceGenome:RGD:621774
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables ribonucleoprotein complex binding activity. Involved in cellular response to Thyroid stimulating hormone; cellular response to cAMP; and positive regulation of translation. Part of cytosolic large ribosomal subunit. Orthologous to human RPLP1 (ribosomal protein lateral stalk subunit P1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 13669.1), Thymus (RPKM 11668.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (71289539..71290872, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (62394008..62395341, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (66862143..66863476, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RPLP1 (e-PCR)
- UniSTS:503125

RPLP1 (e-PCR)
- UniSTS:266204

MARC_5765-5766:997299257:1 (e-PCR)
- UniSTS:269565

PMC156124P1 (e-PCR)
- UniSTS:271359

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoprotein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoprotein complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to Thyroid stimulating hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of translation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic large ribosomal subunit	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: large ribosomal subunit protein P1

Names: 60S acidic ribosomal protein P1; ribosomal protein, large, P1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007604.2 → NP_001007605.1 large ribosomal subunit protein P1

See identical proteins and their annotated locations for NP_001007605.1

Status: PROVISIONAL

Source sequence(s)

BC058151

UniProtKB/Swiss-Prot

P19944

UniProtKB/TrEMBL

A6J567

Related

ENSRNOP00000101776.1, ENSRNOT00000077213.3

Conserved Domains (1) summary

cd05831
Location:6 → 63

Ribosomal_P1; Ribosomal protein P1. This subfamily represents the eukaryotic large ribosomal protein P1. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P1 is located in the L12 stalk, with proteins ...